Journal Article

DZNE-2023-00670

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Impact of low-value medications on quality of life, hospitalization and costs - A longitudinal analysis of patients living with dementia.

Platen, M. (First author)DZNE* ; Flessa, S. ; Teipel, S.DZNE* ; Rädke, A.DZNE* ; Scharf, A.DZNE* ; Mohr, W.DZNE* ; Buchholz, M.DZNE* ; Hoffmann, W.DZNE* ; Michalowsky, B. (Last author)DZNE*

2023
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.13012

Abstract: This study aimed to analyze the impact of low-value medications (Lvm), that is, medications unlikely to benefit patients but to cause harm, on patient-centered outcomes over 24 months.This longitudinal analysis was based on baseline, 12 and 24 months follow-up data of 352 patients with dementia. The impact of Lvm on health-related quality of life (HRQoL), hospitalizations, and health care costs were assessed using multiple panel-specific regression models.Over 24 months, 182 patients (52%) received Lvm at least once and 56 (16%) continuously. Lvm significantly increased the risk of hospitalization by 49% (odds ratio, confidence interval [CI] 95% 1.06-2.09; p = 0.022), increased health care costs by €6810 (CI 95% -707€-14,27€; p = 0.076), and reduced patients' HRQoL (b = -1.55; CI 95% -2.76 to -0.35; p = 0.011).More than every second patient received Lvm, negatively impacting patient-reported HRQoL, hospitalizations, and costs. Innovative approaches are needed to encourage prescribers to avoid and replace Lvm in dementia care.Over 24 months, more than every second patient received low-value medications (Lvm). Lvm negatively impact physical, psychological, and financial outcomes. Appropriate measures are needed to change prescription behaviors.

Keyword(s): Humans (MeSH) ; Quality of Life (MeSH) ; Health Care Costs (MeSH) ; Hospitalization (MeSH) ; Dementia: drug therapy (MeSH) ; Alzheimer's disease ; dementia ; health care costs ; health care resources ; health-related quality of life ; hospitalization ; low-value care

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Contributing Institute(s):

1. Translational Health Care Research (AG Hoffmann)
2. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
3. Interventional Health Care Research (IHCR) (AG Thyrian)
4. AG Michalowsky (AG Michalowsky ; AG Michalowsky)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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