Journal Article

DZNE-2024-00768

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET.

Kaiser, L. ; Quach, S. ; Zounek, A. J. ; Wiestler, B. ; Zatcepin, A.DZNE* ; Holzgreve, A. ; Bollenbacher, A. ; Bartos, L. M. ; Ruf, V. C. ; Böning, G. ; Thon, N. ; Herms, J. ; Riemenschneider, M. J. ; Stöcklein, S. ; Brendel, M.DZNE* ; Rupprecht, R. ; Tonn, J. C. ; Bartenstein, P. ; von Baumgarten, L. ; Ziegler, S. ; Albert, N. L.

2024
Springer-Verl. Heidelberg [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00259-024-06654-5

Abstract: According to the World Health Organization classification for tumors of the central nervous system, mutation status of the isocitrate dehydrogenase (IDH) genes has become a major diagnostic discriminator for gliomas. Therefore, imaging-based prediction of IDH mutation status is of high interest for individual patient management. We compared and evaluated the diagnostic value of radiomics derived from dual positron emission tomography (PET) and magnetic resonance imaging (MRI) data to predict the IDH mutation status non-invasively.Eighty-seven glioma patients at initial diagnosis who underwent PET targeting the translocator protein (TSPO) using [18F]GE-180, dynamic amino acid PET using [18F]FET, and T1-/T2-weighted MRI scans were examined. In addition to calculating tumor-to-background ratio (TBR) images for all modalities, parametric images quantifying dynamic [18F]FET PET information were generated. Radiomic features were extracted from TBR and parametric images. The area under the receiver operating characteristic curve (AUC) was employed to assess the performance of logistic regression (LR) classifiers. To report robust estimates, nested cross-validation with five folds and 50 repeats was applied.TBRGE-180 features extracted from TSPO-positive volumes had the highest predictive power among TBR images (AUC 0.88, with age as co-factor 0.94). Dynamic [18F]FET PET reached a similarly high performance (0.94, with age 0.96). The highest LR coefficients in multimodal analyses included TBRGE-180 features, parameters from kinetic and early static [18F]FET PET images, age, and the features from TBRT2 images such as the kurtosis (0.97).The findings suggest that incorporating TBRGE-180 features along with kinetic information from dynamic [18F]FET PET, kurtosis from TBRT2, and age can yield very high predictability of IDH mutation status, thus potentially improving early patient management.

Keyword(s): Humans (MeSH) ; Female (MeSH) ; Receptors, GABA: genetics (MeSH) ; Receptors, GABA: metabolism (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Isocitrate Dehydrogenase: genetics (MeSH) ; Mutation (MeSH) ; Positron-Emission Tomography: methods (MeSH) ; Glioma: diagnostic imaging (MeSH) ; Glioma: genetics (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Adult (MeSH) ; Brain Neoplasms: diagnostic imaging (MeSH) ; Brain Neoplasms: genetics (MeSH) ; Aged (MeSH) ; Tyrosine: analogs & derivatives (MeSH) ; Image Processing, Computer-Assisted (MeSH) ; Radiomics (MeSH) ; IDH mutation status ; BraTS ; FET PET ; Glioma ; Radiomics ; TSPO PET ; Receptors, GABA ; Isocitrate Dehydrogenase ; TSPO protein, human ; (18F)fluoroethyltyrosine ; Tyrosine

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Contributing Institute(s):

1. Molecular Neurodegeneration (AG Haass)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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