Journal Article (Review Article)

DZNE-2024-01202

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Akinetic crisis and withdrawal syndromes: guideline 'Parkinson's disease' of the German Society of Neurology.

Pötter-Nerger, M. ; Löhle, M.DZNE* ; Höglinger, G. (Last author)DZNE* ; Group, G. P. G. (Collaboration Author)

2024
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00415-024-12649-x

Abstract: The akinetic crisis is a well-known, rare, potentially life-threatening condition in Parkinson's disease with subacute worsening of akinesia, rigidity, fever, impaired consciousness, accompanying vegetative symptoms and transient dopa-resistance. The akinetic crisis was historically supposed to be a 'withdrawal syndrome' in the sense of discontinuation of dopaminergic medication. Recently, other 'withdrawal syndromes' as the specific 'dopamine agonist withdrawal syndrome' or 'deep brain stimulation withdrawal syndrome' have been described as emergency situations with specific subacute symptom constellations. All three conditions require immediate start of the adequate therapy to improve the prognosis. Here, the diagnostic criteria and treatment options of these three acute, severely disabling syndromes will be reported along the current guidelines of the German Parkinson Guideline Group.

Keyword(s): Humans (MeSH) ; Parkinson Disease: drug therapy (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Parkinson Disease: therapy (MeSH) ; Substance Withdrawal Syndrome: diagnosis (MeSH) ; Germany (MeSH) ; Neurology: standards (MeSH) ; Societies, Medical: standards (MeSH) ; Antiparkinson Agents: therapeutic use (MeSH) ; Antiparkinson Agents: adverse effects (MeSH) ; Deep Brain Stimulation: standards (MeSH) ; Practice Guidelines as Topic: standards (MeSH) ; Akinetic crisis ; Deep brain stimulation withdrawal syndrome ; Diagnostic criteria ; Dopamine agonist withdrawal syndrome ; German Parkinson Guideline ; Therapy ; Antiparkinson Agents

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Contributing Institute(s):

1. Clinical Research (Munich) (Clinical Research (Munich))
2. Translational Neurodegeneration (AG Höglinger)
3. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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