Journal Article

DZNE-2024-01239

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Team Science Approaches to Unravel Monogenic Parkinson's Disease on a Global Scale.

Junker, J. ; Lange, L. M.Extern* ; Vollstedt, E.-J. ; Roopnarain, K. ; Doquenia, M. L. M. ; Annuar, A. A. ; Avenali, M. ; Bardien, S. ; Bahr, N. ; Ellis, M. ; Galandra, C. ; Gasser, T.DZNE* ; Heutink, P.DZNE* ; Illarionova, A.DZNE* ; Kanana, Y. ; Keller Sarmiento, I. J. ; Kumar, K. R. ; Lim, S.-Y. ; Madoev, H. ; Mata, I. F. ; Mencacci, N. E. ; Nalls, M. A. ; Padmanabhan, S. ; Shambetova, C. ; Solle, J. C. ; Tan, A.-H. ; Trinh, J. ; Valente, E. M. ; Singleton, A. ; Blauwendraat, C. ; Lohmann, K. ; Fang, Z.-H.DZNE* ; Klein, C. ; Program, G. P. G. (Collaboration Author) ; Junker, J. (Contributor) ; Lange, L. M. (Contributor)Extern* ; Vollstedt, E.-J. (Contributor) ; Roopnarain, K. (Contributor) ; Doquenia, M. L. M. (Contributor) ; Annuar, A. A. (Contributor) ; Avenali, M. (Contributor) ; Bardien, S. (Contributor) ; Bahr, N. (Contributor) ; Ellis, M. (Contributor) ; Galandra, C. (Contributor) ; Gasser, T. (Contributor)Extern* ; Heutink, P. (Contributor)Extern* ; Illarionova, A. (Contributor)Extern* ; Kanana, Y. (Contributor) ; Keller, I. J. (Contributor) ; Kumar, K. R. (Contributor) ; Lim, S.-Y. (Contributor) ; Madoev, H. (Contributor) ; Mata, I. F. (Contributor) ; Mencacci, N. E. (Contributor) ; Nalls's, M. A. (Contributor) ; Padmanabhan, S. (Contributor) ; Shambetova, C. (Contributor) ; Solle, J. (Contributor) ; Tan, A.-H. (Contributor) ; Trinh, J. (Contributor) ; Valente, E. M. (Contributor) ; Singleton, A. (Contributor) ; Blauwendraat, C. (Contributor) ; Lohmann, K. (Contributor) ; Fang, Z.-H. (Contributor)Extern* ; Klein, C. (Contributor)

2024
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.29925

Abstract: Until recently, about three-quarters of all monogenic Parkinson's disease (PD) studies were performed in European/White ancestry, thereby severely limiting our insights into genotype-phenotype relationships at a global scale.To identify the multi-ancestry spectrum of monogenic PD.The first systematic approach to embrace monogenic PD worldwide, The Michael J. Fox Foundation Global Monogenic PD Project, contacted authors of publications reporting individuals carrying pathogenic variants in known PD-causing genes. In contrast, the Global Parkinson's Genetics Program's Monogenic Network took a different approach by targeting PD centers underrepresented or not yet represented in the medical literature.In this article, we describe combining both efforts in a merger project resulting in a global monogenic PD cohort with the buildup of a sustainable infrastructure to identify the multi-ancestry spectrum of monogenic PD and enable studies of factors modifying penetrance and expressivity of monogenic PD.This effort demonstrates the value of future research based on team science approaches to generate comprehensive and globally relevant results. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Humans (MeSH) ; Parkinson Disease: genetics (MeSH) ; Parkinson Disease: therapy (MeSH) ; Genetic Predisposition to Disease (MeSH) ; Genetic Association Studies: methods (MeSH) ; GP2 ; MJFF GMPD ; Parkinson's disease ; monogenic Parkinson's disease ; parkinsonism

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)
2. Genome Biology of Neurodegenerative Diseases (AG Heutink)
3. Core ICRU (ICRU)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)
3. 899 - ohne Topic (POF4-899) (POF4-899)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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