Journal Article

DZNE-2024-01359

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease.

Hofmann, A. (First author)DZNE* ; Häsler, L. M.DZNE* ; Lambert, M.DZNE* ; Kaeser, S.DZNE* ; Gräber-Sultan, S.DZNE* ; Obermüller, U.DZNE* ; Kuder-Buletta, E.DZNE* ; la Fougère, C.DZNE* ; Laske, C.DZNE* ; Vöglein, J.DZNE* ; Levin, J.DZNE* ; Fox, N. C. ; Ryan, N. S. ; Zetterberg, H. ; Llibre-Guerra, J. J. ; Perrin, R. J. ; Ibanez, L. ; Schofield, P. R. ; Brooks, W. S. ; Day, G. S. ; Farlow, M. R. ; Allegri, R. F. ; Chrem Mendez, P. ; Ikeuchi, T. ; Kasuga, K. ; Lee, J.-H. ; Roh, J. H. ; Mori, H. ; Lopera, F. ; Bateman, R. J. ; McDade, E. ; Gordon, B. A. ; Chhatwal, J. P. ; Jucker, M.DZNE* ; Schultz, S. A. ; Network, D. I. A. (Collaboration Author) ; Aguillon, D. (Contributor) ; Aschenbrenner, A. J. (Contributor) ; Baker, B. (Contributor) ; Barthelemy, N. (Contributor) ; Bateman, R. (Contributor) ; Bechara, J. A. (Contributor) ; Benzinger, T. (Contributor) ; Berman, S. B. (Contributor) ; Cash, D. M. (Contributor) ; Chen, A. (Contributor) ; Chen, C. (Contributor) ; Chhatwal Chhatwal, J. P. (Contributor) ; Mendez, P. C. (Contributor) ; Courtney, L. (Contributor) ; Cruchaga, C. (Contributor) ; Daniels, A. J. (Contributor) ; Day, G. S. (Contributor) ; Fagan, A. M. (Contributor) ; Farlow, M. (Contributor) ; Flores, S. (Contributor) ; Franklin, E. (Contributor) ; Goate, A. M. (Contributor) ; Gräber-Sultan, S. (Contributor)Extern* ; Graff-Radford, N. R. (Contributor) ; Gremminger, E. (Contributor) ; Hassenstab, J. (Contributor) ; Herries, E. (Contributor) ; Holtzman, D. M. (Contributor) ; Hornbeck, R. (Contributor) ; Huey, E. D. (Contributor) ; Ikonomovic, S. (Contributor) ; Jackson, K. (Contributor) ; Jarman, S. (Contributor) ; Jerome, G. (Contributor) ; Johnson, E. C. B. (Contributor) ; Joseph-Mathurin, N. (Contributor) ; Karch, C. M. (Contributor) ; Keefe, S. (Contributor) ; Koudelis, D. (Contributor) ; Laske, C. (Contributor)Extern* ; Leon, Y. M. (Contributor) ; Levey, A. I. (Contributor) ; Li, Y. (Contributor) ; Lu, R. (Contributor) ; Marsh, J. (Contributor) ; Martins, R. (Contributor) ; Massoumzadeh, P. (Contributor) ; Masters, C. (Contributor) ; McCullough, A. (Contributor) ; McDade, E. (Contributor) ; McKay, N. (Contributor) ; Minton, M. (Contributor) ; Morris, J. C. (Contributor) ; Nadkarni, N. K. (Contributor) ; Nicklaus, J. (Contributor) ; Niimi, Y. (Contributor) ; Noble, J. M. (Contributor) ; Obermueller, U. (Contributor) ; Picarello, D. M. (Contributor) ; Pulizos, C. (Contributor) ; Ramirez, L. (Contributor) ; Renton, A. E. (Contributor) ; Ringman, J. (Contributor) ; Rizzo, J. (Contributor) ; Rödenbeck, Y. E. (Contributor)Extern* ; Rosa-Neto, P. (Contributor) ; Sabaredzovic, E. (Contributor) ; Salloway, S. (Contributor) ; Sanchez-Valle, R. (Contributor) ; Scott, J. (Contributor) ; Seyfried, N. T. (Contributor) ; Simmons, A. (Contributor) ; Smith, J. (Contributor) ; Smith, H. (Contributor) ; Stauber, J. (Contributor) ; Stout, S. (Contributor) ; Supnet-Bell, C. (Contributor) ; Surace, E. (Contributor) ; Vazquez, S. (Contributor) ; Vöglein, J. (Contributor)Extern* ; Wang, G. (Contributor) ; Wang, Q. (Contributor) ; Xiong, C. (Contributor) ; Xu, X. (Contributor) ; Xu, J. (Contributor)

2024
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-024-52937-8

Abstract: Disease-modifying therapies for Alzheimer's disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament light chain protein (NfL) showing promise for monitoring neurodegeneration and predicting cognitive outcomes. Here, we update and complement previous findings from the Dominantly Inherited Alzheimer Network Observational Study by using matched cross-sectional and longitudinal cerebrospinal fluid (CSF) and plasma samples from 567 individuals, allowing timely comparative analyses of CSF and blood trajectories across the entire disease spectrum. CSF and plasma trajectories were similar at presymptomatic stages, discriminating mutation carriers from non-carrier controls 10-20 years before the estimated onset of clinical symptoms, depending on the statistical model used. However, after symptom onset the rate of change in CSF NfL continued to increase steadily, whereas the rate of change in plasma NfL leveled off. Both plasma and CSF NfL changes were associated with grey-matter atrophy, but not with Aβ-PET changes, supporting a temporal decoupling of Aβ deposition and neurodegeneration. These observations support NfL in both CSF and blood as an early marker of neurodegeneration but suggest that NfL measured in the CSF may be better suited for monitoring clinical trial outcomes in symptomatic AD patients.

Keyword(s): Humans (MeSH) ; Alzheimer Disease: cerebrospinal fluid (MeSH) ; Alzheimer Disease: blood (MeSH) ; Alzheimer Disease: genetics (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Neurofilament Proteins: blood (MeSH) ; Neurofilament Proteins: cerebrospinal fluid (MeSH) ; Male (MeSH) ; Female (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Biomarkers: blood (MeSH) ; Middle Aged (MeSH) ; Cross-Sectional Studies (MeSH) ; Adult (MeSH) ; Longitudinal Studies (MeSH) ; Amyloid beta-Peptides: cerebrospinal fluid (MeSH) ; Amyloid beta-Peptides: blood (MeSH) ; Atrophy (MeSH) ; Gray Matter: pathology (MeSH) ; Gray Matter: diagnostic imaging (MeSH) ; Aged (MeSH) ; Positron-Emission Tomography (MeSH) ; Disease Progression (MeSH) ; Neurofilament Proteins ; Biomarkers ; neurofilament protein L ; Amyloid beta-Peptides

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Contributing Institute(s):

1. Cell Biology of Neurological Diseases (AG Jucker)
2. Parkinson Genetics (AG Gasser)
3. Clinical Research (Munich) (Clinical Research (Munich))

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)
2. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Experiment(s):

1. Longitudinal Study on Dominantly Inherited Alzheimer's Disease

Appears in the scientific report 2024

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