DIAN
Longitudinal Study on Dominantly Inherited Alzheimer's Disease
| Operating body | Deutsches Zentrum für Neurodegenerative Erkrankungen |
| Categories | Experiment |
| Further information: | Website |
| Identifier | EXP:(DE-2719)DIAN-20090101 |
Recent Publications
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Journal Article
Kennedy, J. T. ; Wisch, J. K. ; Boerwinkle, A. H. ; Millar, P. R. ; McKay, N. S. ; Brickman, A. M. ; Chhatwal, J. P. ; Mendez, P. C. ; Christian, B. T. ; Cohen, A. ; Cruchaga, C. ; Daniels, A. ; Flores, S. ; Handen, B. L. ; Hartley, S. L. ; Head, E. ; Ibanez, L. ; Krisnsky-McHale, S. J. ; la Fougere, C. ; Lai, F. ; Laymon, C. M. ; Lee, J. H. ; Lee, J.-H. ; Levin, J.DZNE* ; Llibre-Guerra, J. ; Aguillon, D. F. ; Lott, I. T. ; Mapstone, M. ; McDade, E. ; Morris, J. ; O'Bryant, S. E. ; Price, J. C. ; Rafii, M. S. ; Roh, J. H. ; Rosas, H. D. ; Schupf, N. ; Supnet-Bell, C. ; Xiong, C. ; Zaman, S. ; Benzinger, T. L. S. ; Gordon, B. A. ; Ances, B. M. ; Alzheimer's Brain Consortium - Down Syndrome ; Network, t. D. I. A. (Collaboration Author)
Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.
Alzheimer's and dementia 22(1), e71103 (2026) [10.1002/alz.71103]2026
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Pérez-Millan, A. ; Falgàs, N. ; Bosch, B. ; et al
Cortical asymmetry in autosomal dominant Alzheimer's disease progression.
Brain communications 8(1), fcaf488 (2026) [10.1093/braincomms/fcaf488]2026
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Journal Article
McCullough, A. ; Chen, C. D. ; Gordon, B. A. ; et al
Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN-TU-001 trial.
Alzheimer's and dementia 21(7), e70347 (2025) [10.1002/alz.70347]2025
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Oeckl, P. (First author)DZNE* ; Mayer, B. ; Bateman, R. J. ; Day, G. S. ; Fox, N. C. ; Huey, E. D. ; Ibanez, L. ; Ikeuchi, T. ; Jucker, M.DZNE* ; Lee, J.-H. ; Levin, J.DZNE* ; Llibre-Guerra, J. J. ; Lopera, F. ; McDade, E. ; Morris, J. C. ; Niimi, Y. ; Roh, J. H. ; Sánchez-Valle, R. ; Schofield, P. R. ; Otto, M. ; Network, D. I. A. (Collaboration Author)
Early increase of the synaptic blood marker β-synuclein in asymptomatic autosomal dominant Alzheimer's disease.
Alzheimer's and dementia 21(4), e70146 (2025) [10.1002/alz.70146]2025
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Journal Article
Wiels, W. A. ; Oomens, J. E. ; Engelborghs, S. ; et al
Depressive Symptoms and Amyloid Pathology.
JAMA psychiatry 82(3), 296 - 310 (2025) [10.1001/jamapsychiatry.2024.4305]2025
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Hofmann, A. (First author)DZNE* ; Häsler, L. M.DZNE* ; Lambert, M.DZNE* ; et al
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease.
Nature Communications 15(1), 9982 (2024) [10.1038/s41467-024-52937-8]2024
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Son, H. J. ; Kim, J. S. ; Bateman, R. J. ; Kim, S. ; Llibre-Guerra, J. J. ; Day, G. S. ; Chhatwal, J. P. ; Berman, S. B. ; Schofield, P. R. ; Jucker, M.DZNE* ; Levin, J.DZNE* ; Lee, J.-H. ; Perrin, R. J. ; Morris, J. C. ; Cruchaga, C. ; Hassenstab, J. ; Salloway, S. P. ; Lee, J.-H. ; Daniels, A. ; Network, D. I. A. (Collaboration Author)
Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease.
Neurology 103(7), e209766 (2024) [10.1212/WNL.0000000000209766]2024
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Levin, J. (First author)DZNE* ; Baiardi, S. ; Quadalti, C. ; Rossi, M. ; Mammana, A. ; Vöglein, J.DZNE* ; Bernhardt, A.DZNE* ; Perrin, R. J. ; Jucker, M.DZNE* ; Preische, O.DZNE* ; Hofmann, A.DZNE* ; Höglinger, G. U.DZNE* ; Cairns, N. J. ; Franklin, E. E. ; Chrem, P. ; Cruchaga, C. ; Berman, S. B. ; Chhatwal, J. P. ; Daniels, A. ; Day, G. S. ; Ryan, N. S. ; Goate, A. M. ; Gordon, B. A. ; Huey, E. D. ; Ibanez, L. ; Karch, C. M. ; Lee, J.-H. ; Llibre-Guerra, J. ; Lopera, F. ; Masters, C. L. ; Morris, J. C. ; Noble, J. M. ; Renton, A. E. ; Roh, J. H. ; Frosch, M. P. ; Keene, C. D. ; McLean, C. ; Sanchez-Valle, R. ; Schofield, P. R. ; Supnet-Bell, C. ; Xiong, C. ; Giese, A. ; Hansson, O. ; Bateman, R. J. ; McDade, E. ; Network, D. I. A. (Collaboration Author) ; Parchi, P.
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden.
Alzheimer's and dementia 20(6), 4351 - 4365 (2024) [10.1002/alz.13818]2024
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Journal Article
Johnson, E. C. B. ; Bian, S. ; Haque, R. U. ; et al
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
Nature medicine 29(8), 1979 - 1988 (2023) [10.1038/s41591-023-02476-4]2023
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Schultz, S. A. ; Shirzadi, Z. ; Schultz, A. P. ; Liu, L. ; Fitzpatrick, C. D. ; McDade, E. ; Barthelemy, N. R. ; Renton, A. ; Esposito, B. ; Joseph-Mathurin, N. ; Cruchaga, C. ; Chen, C. D. ; Goate, A. ; Allegri, R. F. ; Benzinger, T. L. S. ; Berman, S. ; Chui, H. C. ; Fagan, A. M. ; Farlow, M. R. ; Fox, N. C. ; Gordon, B. A. ; Day, G. S. ; Graff-Radford, N. R. ; Hassenstab, J. J. ; Hanseeuw, B. J. ; Hofmann, A.DZNE* ; Jack, C. R. ; Jucker, M.DZNE* ; Karch, C. M. ; Koeppe, R. A. ; Lee, J.-H. ; Levey, A. I. ; Levin, J.DZNE* ; Martins, R. N. ; Mori, H. ; Morris, J. C. ; Noble, J. ; Perrin, R. J. ; Rosa-Neto, P. ; Salloway, S. P. ; Sanchez-Valle, R. ; Schofield, P. R. ; Xiong, C. ; Johnson, K. A. ; Bateman, R. J. ; Sperling, R. A. ; Chhatwal, J. P. ; Investigators, D. I. A. N. (Collaboration Author)
Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease.
Aging cell 22(8), e13871 (2023) [10.1111/acel.13871]2023
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