Journal Article

DZNE-2025-00303

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Supporting older people with cognitive impairment during and after hospital stays with intersectoral care management (intersec-CM)-results of a randomised clinical trial.

Boekholt, M. (First author)DZNE* ; Nikelski, A. ; Schumacher-Schönert, F.DZNE* ; Kracht, F.DZNE* ; Vollmar, H. C. ; Hoffmann, W.DZNE* ; Kreisel, S. H. ; Thyrian, J. R. (Last author)DZNE*

2025
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/ageing/afaf011

Abstract: The transition from hospital to primary care is a risk factor for negative health outcomes in people with cognitive impairment.To test the effectiveness of intersectoral care management during the transition from hospital to primary care on repeated admission to hospital, functionality and institutionalisation in people with cognitive impairment.Longitudinal multisite randomised controlled trial with two arms (care as usual and intersectoral care management) and two follow-ups 3 and 12 months after discharge.Three hospitals in two different primary care regions in Germany.n = 401 people with cognitive impairment: community-dwelling, age 70+. Randomised into control (n = 192) or intervention (n = 209).Primary outcomes for the study after 3 months: admission to hospital, physical and instrumental functionality. Primary outcome after 12 months: institutionalisation, physical and instrumental functionality. Secondary outcomes: health-related quality of life, depressive symptoms, cognitive status and frailty. Statistical analyses include descriptive analyses as well as univariate and multivariate regression models for all outcomes.There was no statistically significant effect of the intervention on hospital admission and activities of daily living after 3 months, as well as on institutionalisation and activities of daily living after 12 months. There were significantly fewer participants in the intervention group readmitted to the hospital 12 months after discharge.Analyses show a significant effect on health-related quality of life 3 months and 12 months after discharge. Depressive symptoms were significantly less likely in the intervention group 3 months after discharge. No effects on cognition or frailty.Intersectoral care management supports people with cognitive impairment during discharge and transition. Even though we were not able to show an impact of the intervention on the chosen primary outcomes everyday functionality and institutionalisation, the effects on health-related quality of life, hospital admission rate and mental health are solid indicators for an improved individual situation.ClinicalTrials.gov, NCT03359408; https://clinicaltrials.gov/ct2/show/NCT03359408.

Keyword(s): Humans (MeSH) ; Male (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Cognitive Dysfunction: therapy (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Quality of Life (MeSH) ; Aged, 80 and over (MeSH) ; Germany (MeSH) ; Activities of Daily Living (MeSH) ; Patient Discharge (MeSH) ; Primary Health Care (MeSH) ; Institutionalization (MeSH) ; Longitudinal Studies (MeSH) ; Cognition (MeSH) ; Time Factors (MeSH) ; Patient Readmission (MeSH) ; Frailty: therapy (MeSH) ; Frailty: diagnosis (MeSH) ; Frailty: psychology (MeSH) ; Germany ; cognitive impairment ; dementia care management ; hospital discharge ; older people ; randomised controlled trial

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Contributing Institute(s):

1. Interventional Health Care Research (IHCR) (AG Thyrian)
2. Translational Health Care Research (AG Hoffmann)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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