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| Home > Publications Database > Myelin water fraction mapping with joint inversion of gradient-echo and spin-echo data. |
| Journal Article | DZNE-2025-00434 |
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2025
Springer
Heidelberg
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Please use a persistent id in citations: doi:10.1007/s10334-025-01235-5
Abstract: Accurate estimation of brain myelin-water content from multi-echo data is challenging due to the inherent ill-posedness of the inversion problem. In this study, we propose a novel method for myelin-water imaging that jointly utilizes gradient-echo and spin-echo imaging data to enhance the accuracy of myelin-water estimation.Multi-echo gradient-echo and spin-echo data were simulated and acquired in vivo. The simulations are based on a parameterized myelin and free water signal model, which is also used for the inversion by means of nonlinear local-search optimization. Single inversions of the individual datasets as well as joint inversion of the combined datasets were performed on simulated and real data. While single inversions estimate either the T 2 or T 2 ∗ relaxation spectrum, the joint inversion estimates both spectra simultaneously.Simulation results show that the accuracy of myelin-water imaging improves when jointly inverting gradient-echo and spin-echo synthetic data. In vivo experiments show that the joint inversion of both datasets leads to sharper and more distinct myelin-water images as compared to the individual inversions.Our method addresses the ill-posed nature of the myelin-water inversion problem by leveraging complementary information from multi-echo gradient-echo and multi-echo spin-echo imaging sequences, thus improving the reliability of myelin-water quantification.
Keyword(s): Spin Labels (MeSH) ; Myelin Sheath: chemistry (MeSH) ; Humans (MeSH) ; Algorithms (MeSH) ; Water: chemistry (MeSH) ; Brain: diagnostic imaging (MeSH) ; Image Processing, Computer-Assisted: methods (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Computer Simulation (MeSH) ; Echo-Planar Imaging: methods (MeSH) ; Adult (MeSH) ; Reproducibility of Results (MeSH) ; Male (MeSH) ; Echo-Planar Imaging (MeSH) ; T 2 and T 2 ∗ relaxation spectra ; Joint inversion ; Myelin water fraction ; Myelin water imaging ; Water
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