Journal Article

DZNE-2025-00942

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tackling gender in progressive supranuclear palsy: Male patients present more apathy.

Ye, L. ; Greten, S. ; Wilkens, I. ; Wegner, F. ; Krey, L. ; Höllerhage, M. ; Pötter-Nerger, M. ; Zeitzschel, M. ; Hagena, K. ; Kassubek, J.DZNE* ; Süß, P. ; Winkler, J. ; Berg, D. ; Paschen, S. ; Tönges, L. ; Gruber, D. ; Gandor, F. ; Jost, W. H. ; Kühn, A. A.DZNE* ; Claus, I. ; Warnecke, T. ; Pedrosa, D. J. ; Eggers, C. ; Trenkwalder, C. ; Classen, J. ; Schwarz, J. ; Schnitzler, A. ; Höglinger, G.Extern* ; Klietz, M.

2025
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.1177/1877718X251343094

Abstract: Gender differences in progressive supranuclear palsy (PSP) may become relevant for clinical trials, treatment decisions and patient counseling. To study gender associated differences we conducted a retrospective data analysis of 191 male and 157 female PSP patients from a large multicenter observational cohort in Germany. While no differences in motor skills, disease severity, daily living abilities, global cognitive status and depressive symptoms were observed between genders, male patients showed significantly higher apathy scores, a finding also noted in other neurological diseases. In this study, apart from male patients exhibiting higher levels of apathy, no significant disease-specific gender differences were observed in PSP patients.

Keyword(s): Humans (MeSH) ; Supranuclear Palsy, Progressive: physiopathology (MeSH) ; Supranuclear Palsy, Progressive: psychology (MeSH) ; Supranuclear Palsy, Progressive: complications (MeSH) ; Male (MeSH) ; Apathy: physiology (MeSH) ; Female (MeSH) ; Aged (MeSH) ; Retrospective Studies (MeSH) ; Middle Aged (MeSH) ; Sex Factors (MeSH) ; Severity of Illness Index (MeSH) ; Germany (MeSH) ; Aged, 80 and over (MeSH) ; Depression: etiology (MeSH) ; apathy ; gender ; progressive supranuclear palsy

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Contributing Institute(s):

1. Clinical Study Center (Ulm) (Clinical Study Center (Ulm))
2. Movement Disorders (Parkinson's disease, Dystonia) (AG Kühn)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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