Journal Article

DZNE-2025-00953

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves.

Sammons, R. P. ; Masserini, S. ; Moreno Velasquez, L. ; Metodieva, V. D. ; Cano, G. ; Sannio, A. ; Orlando, M. ; Maier, N. ; Kempter, R. ; Schmitz, D. (Last author)DZNE*

2025
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: doi:10.7554/eLife.98653

Abstract: The CA3 region of the hippocampus is the major site of sharp wave initiation, and a brain region crucially involved in learning and memory. Highly recurrent connectivity within its excitatory network is thought to underlie processes involved in memory formation. Recent work has indicated that distinct subpopulations of pyramidal neurons within this region may contribute differently to network activity, including sharp waves, in CA3. Exactly how these contributions may arise is not yet known. Here, we disentangle the local connectivity between two distinct CA3 cell types in mice: thorny and athorny pyramidal cells. We find an asymmetry in the connectivity between these two populations, with athorny cells receiving strong input from both athorny and thorny cells. Conversely, the thorny cell population receives very little input from the athorny population. Computational modeling suggests that this connectivity scheme may determine the sequential activation of these cell types during large network events such as sharp waves.

Keyword(s): CA3 ; connectivity ; hippocampus ; learning ; memory ; mouse ; neuroscience ; pyramidal cells ; sharp waves

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Contributing Institute(s):

1. Network Dysfunction (AG Schmitz)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2025

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