Contribution to a book

DZNE-2025-01016

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The role of environmental toxins and inflammation in Parkinson's disease pathophysiology: a historical perspective and research-based evidence

Pan-Montojo, F. ; Löwenbrück, K.DZNE* ; Reichmann, H.

2020
Elsevier

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Please use a persistent id in citations: doi:10.1016/B978-0-12-815946-0.00003-X

Abstract: Parkinson's disease (PD) was first described by the English physician James Parkinson in his work An Essay on the Shaking Palsy in 1817. This correlates well with the beginning of the industrial and chemical revolution in Europe during the late 18th and 19th centuries. This period and the time afterward are linked to the increased production and use of chemicals and pesticides. In this chapter, we review (1) the epidemiological evidence linking the appearance of PD to an increase in exposure to environmental toxins, and (2) the possible mechanisms underlying this correlation obtained from in vitro and in vivo experimental studies.

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Contributing Institute(s):

1. Translational Parkinson Research (AG Falkenburger)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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