Journal Article

DZNE-2025-01150

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Speech Differences between Multiple System Atrophy and Parkinson's Disease.

Hähnel, T. ; Nemitz, A. ; Schön, K. ; Berger, L. ; Vogel, A. ; Gruber, D. ; Schnalke, N.Extern* ; Bräuer, S.DZNE* ; Falkenburger, B. H.DZNE* ; Gandor, F.

2025
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mdc3.70094

Abstract: Delineation of Parkinson's disease (PD) from multiple system atrophy (MSA) can be challenging in early disease stages. Speech characteristics have been studied as digital biomarkers in PD and ataxias. Currently, data on speech in MSA is limited.To determine whether speech characteristics can serve as a digital biomarker to differentiate between MSA and PD.Twenty-one MSA patients and 23 PD patients underwent a battery of speech assessments: text reading, sustained phonation and diadochokinetic tasks. Speech characteristics were extracted using the software, Praat.MSA and PD speech can be described by three meaningful factors. MSA speech exhibited more reading pauses, higher pitch variability, prolonged syllables, and a more irregular speech rhythm, allowing differentiation from PD with a ROC-AUC of 0.89. Speech characteristics were correlated with motor impairment and disease severity.MSA can be differentiated from PD with good accuracy using speech analysis.

Keyword(s): Humans (MeSH) ; Multiple System Atrophy: complications (MeSH) ; Multiple System Atrophy: diagnosis (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Female (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Middle Aged (MeSH) ; Speech Disorders: etiology (MeSH) ; Speech Disorders: diagnosis (MeSH) ; Speech: physiology (MeSH) ; ROC Curve (MeSH) ; Parkinson's disease ; dysarthria ; multiple system atrophy ; speech ; voice

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Contributing Institute(s):

1. Translational Parkinson Research (AG Falkenburger)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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