Journal Article

DZNE-2025-01319

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity.

Su, J. ; Gupta, R. ; van Hoof, S.DZNE* ; Kreye, J.DZNE* ; Prüß, H.DZNE* ; Spielman, B. ; Brimberg, L. ; Volpe, B. T. ; Huerta, P. T. ; Diamond, B.

2025
Nature Publishing Group London

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Please use a persistent id in citations: doi:10.1038/s41398-025-03677-w

Abstract: Maternal anti-Caspr2 (Contactin-associated protein-like 2) antibodies have been associated with increased risk for autism spectrum disorder (ASD). Previous studies have shown that in utero exposure to anti-Caspr2 antibodies results in a phenotype with ASD-like features in male mice. Here we ask whether four newly generated antibodies against Caspr2 are pathogenic to the developing fetal brain and whether they function through similar means. Our results show that these novel anti-Caspr2 antibodies recognize different epitopes of Caspr2. In utero exposure to these antibodies elicits differential behavioral phenotypes in male offspring, as demonstrated in the social interaction task, as well as phenotypic alterations in the open-field and light-dark tasks. These results demonstrate variability in the antigenic specificity and pathogenicity of anti-Caspr2 antibodies which may have clinical implications.

Keyword(s): Animals (MeSH) ; Nerve Tissue Proteins: immunology (MeSH) ; Male (MeSH) ; Female (MeSH) ; Mice (MeSH) ; Autism Spectrum Disorder: immunology (MeSH) ; Membrane Proteins: immunology (MeSH) ; Pregnancy (MeSH) ; Autoantibodies: immunology (MeSH) ; Prenatal Exposure Delayed Effects: immunology (MeSH) ; Behavior, Animal (MeSH) ; Brain: immunology (MeSH) ; Brain: embryology (MeSH) ; Humans (MeSH) ; Nerve Tissue Proteins ; Membrane Proteins ; Autoantibodies ; CNTNAP2 protein, mouse

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Contributing Institute(s):

1. Autoimmune Encephalopathies (AG Prüß)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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