Journal Article

DZNE-2025-01363

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Association of cancer with neuropathological markers of Alzheimer's disease and related dementias.

Teipel, S. (First author)DZNE* ; Akmatov, M. ; Michalowsky, B.DZNE* ; Junghanss, C. ; Holstiege, J. ; Bohlken, J.

2025
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/dad2.70222

Abstract: We assessed associations of cancer diagnoses with neuropathology of Alzheimer's disease (AD) and related dementias.We retrieved 2288 cases from the National Alzheimer Coordinating Center (NACC) cohort with available information on cancer diagnoses and neuropathological scoring of Braak stages, Thal amyloid phases, neuritic plaques, TDP-43 pathology, and Lewy body pathology. We used Bayesian ordinal regression to assess associations of prevalent or incident cancer diagnoses with global cognition and postmortem neuropathological scores.We found extreme evidence (Bayes factor [BF] > 2000) that both prevalent and incident cancer diagnoses were associated with better global cognition, strong evidence (BF = 26) for an association of a prevalent cancer diagnosis with lower TDP-43 pathology, and weak evidence (BF = 3.2) for an association with lower Lewy body pathology.Our data suggest that selective survival and biological effects may contribute to the lower risk of dementia in people with a cancer diagnosis.A prevalent diagnosis of cancer was associated with a lower risk of cognitive decline in older individuals.A prevalent diagnosis of cancer was associated with a lower risk of TDP-43 pathology and Lewy body pathology in older individuals.Effects of cancer on TDP-43 pathology were maintained when controlling for degree of cognitive decline.

Keyword(s): Alzheimer's disease pathology ; Braak stages ; TDP‐43 pathology ; protective factor

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
2. Patient-Reported Outcomes and Health Economics Research (AG Michalowsky)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DEAL Wiley ; DOAJ Seal ; Emerging Sources Citation Index ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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