Journal Article (Review Article)

DZNE-2026-00246

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Adult neurogenesis: New neurons, new opportunities.

Doludda, B. (First author)DZNE* ; Barde, W.DZNE* ; D'Egidio, F. ; Fitzsimons, C. P. ; Frisén, J. ; Gage, F. H. ; Jessberger, S. ; Lazarov, O. ; Lie, D. C. ; Lucassen, P. J. ; de Lucia, C. ; Salta, E. ; Song, H. ; Song, J. ; Thuret, S. ; Toda, T.DZNE* ; Kempermann, G. (Last author)DZNE*

2026
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.stem.2026.01.014

Abstract: The 38 currently registered clinical trials with the keyword 'adult neurogenesis' indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neurogenesis without stem cell activity, (3) the complex functionality beyond the hippocampus, and (4) evolutionary and computational theory, including neurogenic neural networks for artificial intelligence.

Keyword(s): Neurogenesis: physiology (MeSH) ; Humans (MeSH) ; Neurons: cytology (MeSH) ; Neurons: physiology (MeSH) ; Animals (MeSH) ; Hippocampus: cytology (MeSH) ; Hippocampus: physiology (MeSH) ; Adult (MeSH) ; Neural Stem Cells: cytology (MeSH) ; hippocampus ; learning ; neural networks ; plasticity ; stem cells

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Contributing Institute(s):

1. Adult Neurogenesis (AG Kempermann)
2. Nuclear Architecture in Neural Plasticity and Aging (AG Toda)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 20 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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