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| Home > In process > Case 53: Second Generation Tau-PET in a Case with Arteriovenous Malformation and Mild Cognitive Impairment |
| Home > In process > Case 53: Second Generation Tau-PET in a Case with Arteriovenous Malformation and Mild Cognitive Impairment |
| Contribution to a book | DZNE-2026-00537 |
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2025
Springer Nature Switzerland
Cham
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Please use a persistent id in citations: doi:10.1007/978-3-032-00522-9_53
Abstract: This case highlights a diagnostic challenge in a 63-year-old female with mild cognitive impairment (MCI) and an arteriovenous malformation (AVM) in the right parieto-occipital brain region. While the patient exhibited minor memory deficits with preserved daily function, a tau-PET scan using [18F]PI-2620 was performed to evaluate possible underlying tauopathy. The static tau-PET images revealed moderate tracer uptake in the right temporal lobe—patterned similarly to early Alzheimer’s disease (AD)—while early-phase images indicated regional hypoperfusion. However, dynamic tau-PET showed no corresponding increase in tracer binding in the same temporal region but did highlight increased uptake in areas proximal to the AVM. Coregistration with MRI revealed that all regions of elevated tracer activity were located adjacent to the vascular malformation. The patient’s cognitive profile remained relatively stable over a follow-up period of four years, providing further evidence that the observed PET signal likely represented non-specific tracer binding rather than neurodegenerative tauopathy. This case underscores the critical role of integrating molecular and structural or functional imaging modalities and the necessity of cautious interpretation in patients with structural brain anomalies. Tau-PET findings must be correlated with anatomical and clinical context to avoid misdiagnosis and inappropriate management.
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