Journal Article

DZNE-2026-00851

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Feasibility of short imaging protocols for [18F]fluordeprenyl-D2 PET in autoimmune encephalitis and multiple system atrophy.

Tagnin, L. ; Dorneich, J. S. ; Zeinaki, M. ; Vogler, L. ; Sanzo, L. ; Gnörich, J. S.DZNE* ; Katzdobler, S.DZNE* ; Masouris, I.DZNE* ; Jäck, A.DZNE* ; Bernhardt, A. M.Extern* ; Rauchmann, B. S.Extern* ; Stöcklein, S.Extern* ; Simmet, M. ; Joseph, E.Extern* ; Lindner, S. ; Koglin, N. ; Mueller, A. ; Stephens, A. W. ; Bischof, G. N. ; Frontzkowski, L. K. ; Franzmeier, N. ; Werner, R. A. ; Gernert, J. A. ; Hopfner, F.DZNE* ; Höglinger, G. U.DZNE* ; Perneczky, R.DZNE* ; Kurz, C. ; Kümpfel, T. ; Kerschensteiner, M. ; Thaler, F. S. ; Levin, J.DZNE* ; Brendel, M. (Last author)DZNE*

2026
Springer-Verl. Heidelberg [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00259-026-07932-0

Abstract: [18F]fluorodeprenyl-D2 ([18F]F-DED) positron emission tomography (PET) imaging detects reactive astrogliosis in patients with autoimmune encephalitis (AIE) and multiple system atrophy (MSA). Although dynamic 60-min acquisitions are established, shorter static imaging protocols are desirable for severely impaired patients. This study investigated the feasibility of short static time windows for [18F]F-DED PET imaging in AIE and MSA.Dynamic 60-min [18F]F-DED PET scans were analyzed in 20 patients with AIE, 20 patients with MSA (MSA-P/MSA-C), and 16 controls (CTRL). Disease-related lesions were manually segmented based on visually detectable positive PET-signal in AIE and MSA predilection sites (i.e. mesial temporal lobe, posterior putamen, cerebellar deep white matter), and standardized uptake value ratios (SUVr; cerebellar cortex as a reference tissue) were calculated for consecutive 10-min intervals. Advanced kinetic parameters (DVR, VTr) were derived using Logan plot and a one-tissue compartment model (1TC2k) with image-derived input functions, both applying the cerebellar cortex as a reference tissue.Static images acquired between 10 and 60 min p.i. showed good image contrast and signal-to-noise ratio. SUVr of lesions increased over time and approached a plateau at approximately 50-60 min p.i.. The strongest agreement between SUVr and DVR was observed between 30 and 50 min p.i.. Late-phase SUVr outperformed kinetic parameters in discriminating lesions from healthy tissue in both AIE and MSA.Short static [18F⁸ ]F-DED PET acquisitions are clinically robust for detecting neuroinflammation in AIE and MSA. A late static acquisition between 30-50 min p.i. provides the optimal balance between accuracy and scanning efficiency.

Keyword(s): Humans (MeSH) ; Positron-Emission Tomography: methods (MeSH) ; Female (MeSH) ; Feasibility Studies (MeSH) ; Male (MeSH) ; Multiple System Atrophy: diagnostic imaging (MeSH) ; Middle Aged (MeSH) ; Encephalitis: diagnostic imaging (MeSH) ; Aged (MeSH) ; Time Factors (MeSH) ; Adult (MeSH) ; Hashimoto Disease: diagnostic imaging (MeSH) ; Autoimmune encephalitis ; MAO-B PET ; Multiple system atrophy ; Short imaging window ; [18F]fluordeprenyl-D2

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Contributing Institute(s):

1. Molecular Neurodegeneration (AG Haass)
2. Clinical Research (Munich) (Clinical Research (Munich))
3. Translational Neurodegeneration (AG Höglinger)
4. Vascular Cognitive Impairment & Post-Stroke Dementia (AG Dichgans)
5. Clinical Neurodegeneration (AG Levin)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)
2. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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