Journal Article

DZNE-2020-05444

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Precuneus Structure Changes in Amnestic Mild Cognitive Impairment.

Haussmann, R. ; Werner, A. ; Gruschwitz, A. ; Osterrath, A.DZNE* ; Lange, J. ; Donix, K. L. ; Linn, J. ; Donix, M. (Last author)DZNE*

2017
Sage Thousand Oaks, Calif.

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Please use a persistent id in citations: doi:10.1177/1533317516678087

Abstract: Patients with amnestic mild cognitive impairment (aMCI) are at risk for developing Alzheimer's disease. Due to their prominent memory impairment, structural magnetic resonance imaging (MRI) often focuses on the hippocampal region. However, recent positron-emission tomography data suggest that within a network of frontal and temporal changes, patients with aMCI show metabolic alterations in the precuneus, a key region for higher cognitive functions. Using high-resolution MRI and whole-brain cortical thickness analyses in 28 patients with aMCI and 25 healthy individuals, we wanted to investigate whether structural changes in the precuneus would be associated with cortical thickness reductions in frontal and temporal brain regions in patients with aMCI. In contrast to healthy people, patients with aMCI showed an association of cortical thinning in the precuneus with predominantly left-hemispheric thickness reductions in medial temporal and frontal cortices. Our data highlight structural neuronal network characteristics among patients with aMCI.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Amnesia: pathology (MeSH) ; Cerebral Cortex: pathology (MeSH) ; Cognitive Dysfunction: pathology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Parietal Lobe: pathology (MeSH)

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Contributing Institute(s):

1. DZNE before 2020 (Pre 2020)
2. Technology Platform Neurobiology of Behaviour (AG Garthe)
3. Translational Parkinson Research (AG Falkenburger)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2017

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Web of Science Core Collection

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