Journal Article

DZNE-2020-06318

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.

van der Lee, S. J. ; Teunissen, C. E. ; Pool, R. ; Shipley, M. J. ; Teumer, A. ; Chouraki, V. ; Melo van Lent, D.DZNE* ; Tynkkynen, J. ; Fischer, K. ; Hernesniemi, J. ; Haller, T. ; Singh-Manoux, A. ; Verhoeven, A. ; Willemsen, G. ; de Leeuw, F. A. ; Wagner, H. ; van Dongen, J. ; Hertel, J. ; Budde, K. ; Willems van Dijk, K. ; Weinhold, L. ; Ikram, M. A. ; Pietzner, M. ; Perola, M. ; Wagner, M.DZNE* ; Friedrich, N. ; Slagboom, P. E. ; Scheltens, P. ; Yang, Q. ; Gertzen, R. E. ; Egert, S. ; Li, S. ; Hankemeier, T. ; van Beijsterveldt, C. E. M. ; Vasan, R. S. ; Maier, W.DZNE* ; Peeters, C. F. W. ; Grabe, H.DZNE* ; Ramirez, A. ; Seshadri, S. ; Metspalu, A. ; Kivimäki, M. ; Salomaa, V. ; Demirkan, A. ; Boomsma, D. I. ; van der Flier, W. M. ; Amin, N. ; van Duijn, C. M.

2018
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jalz.2017.11.012

Abstract: Identifying circulating metabolites that are associated with cognition and dementia may improve our understanding of the pathogenesis of dementia and provide crucial readouts for preventive and therapeutic interventions.We studied 299 metabolites in relation to cognition (general cognitive ability) in two discovery cohorts (N total = 5658). Metabolites significantly associated with cognition after adjusting for multiple testing were replicated in four independent cohorts (N total = 6652), and the associations with dementia and Alzheimer's disease (N = 25,872) and lifestyle factors (N = 5168) were examined.We discovered and replicated 15 metabolites associated with cognition including subfractions of high-density lipoprotein, docosahexaenoic acid, ornithine, glutamine, and glycoprotein acetyls. These associations were independent of classical risk factors including high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, and apolipoprotein E (APOE) genotypes. Six of the cognition-associated metabolites were related to the risk of dementia and lifestyle factors.Circulating metabolites were consistently associated with cognition, dementia, and lifestyle factors, opening new avenues for prevention of cognitive decline and dementia.

Keyword(s): Adult (MeSH) ; Aged (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Biomarkers: metabolism (MeSH) ; Cognitive Dysfunction: metabolism (MeSH) ; Cohort Studies (MeSH) ; Dementia: metabolism (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Life Style (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Reproducibility of Results (MeSH) ; Risk Factors (MeSH) ; Biomarkers

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Contributing Institute(s):

1. Neuropsychology (AG Wagner)
2. U Clinical Researchers - Bonn (U Clinical Researchers - Bonn)
3. Biomarkers of Dementia in the General Population (AG Grabe)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2018

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF >= 15 ; JCR ; SCOPUS ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Melo van Lent, D. (First author)DZNE* ; Wagner, M.DZNE* ; Maier, W.DZNE* ; Grabe, J. (Last author)DZNE*
Erratum to 'Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies' [Alzheimer's & Dementia 2018;14:707-22.].
Alzheimer's and dementia 15(2), 319-319 (2019) [10.1016/j.jalz.2019.01.002]2019   Files BibTeX | EndNote: XML, Text | RIS

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