Journal Article

DZNE-2020-07008

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia.

Alexopoulos, P. (Corresponding author) ; Thierjung, N. ; Economou, P. ; Werle, L. ; Buhl, F. ; Kagerbauer, S. ; Papanastasiou, A. D. ; Grimmer, T. ; Gourzis, P. ; Berthele, A. ; Hemmer, B. ; Kübler, H. ; Martin, J. ; Politis, A. ; Perneczky, R. (Last author)DZNE*

2019
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JAD-181088

Abstract: Cost- and time-effective markers of Alzheimer’s disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N = 33) are significantly lower (p < 0.01) than those of cognitively healthy elderly individuals without AD (N = 39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.

Keyword(s): Aged (MeSH) ; Alzheimer Disease: blood (MeSH) ; Alzheimer Disease: cerebrospinal fluid (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Amyloid beta-Protein Precursor: blood (MeSH) ; Amyloid beta-Protein Precursor: cerebrospinal fluid (MeSH) ; Biomarkers: blood (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Dementia: blood (MeSH) ; Dementia: diagnosis (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; tau Proteins: cerebrospinal fluid (MeSH)

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Contributing Institute(s):

1. Clinical Neurodegeneration (AG Levin)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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