Journal Article

DZNE-2020-00343

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.

Berdugo-Vega, G. ; Arias-Gil, G. ; López-Fernández, A. ; Artegiani, B. ; Wasielewska, J. M. ; Lee, C.-C. ; Lippert, M. T. ; Kempermann, G.DZNE* ; Takagaki, K. ; Calegari, F. (Corresponding author)

2020
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-019-14026-z

Abstract: Functional plasticity of the brain decreases during ageing causing marked deficits in contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a prime example of hippocampal plasticity promoting the contextualisation of information and dramatically decreases during ageing. We found that a genetically-driven expansion of neural stem cells by overexpression of the cell cycle regulators Cdk4/cyclinD1 compensated the age-related decline in neurogenesis. This triggered an overall inhibitory effect on the trisynaptic hippocampal circuit resulting in a changed profile of CA1 sharp-wave ripples known to underlie memory consolidation. Most importantly, increased neurogenesis rescued the age-related switch from hippocampal to striatal learning strategies by rescuing allocentric navigation and contextual memory. Our study demonstrates that critical aspects of hippocampal function can be reversed in old age, or compensated throughout life, by exploiting the brain's endogenous reserve of neural stem cells.

Keyword(s): Aging: physiology (MeSH) ; Animals (MeSH) ; Cyclin D1: metabolism (MeSH) ; Cyclin-Dependent Kinase 4: metabolism (MeSH) ; Female (MeSH) ; Hippocampus: physiology (MeSH) ; Learning: physiology (MeSH) ; Memory: physiology (MeSH) ; Memory Consolidation: physiology (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Neural Stem Cells: physiology (MeSH) ; Neurogenesis: physiology (MeSH) ; Ccnd1 protein, mouse ; Cyclin D1 ; Cdk4 protein, mouse ; Cyclin-Dependent Kinase 4

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Contributing Institute(s):

1. Adult Neurogenesis (AG Kempermann)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Berdugo-Vega, G. ; Arias-Gil, G. ; López-Fernández, A. ; Artegiani, B. ; Wasielewska, J. M.Extern* ; Lee, C.-C. ; Lippert, M. T. ; Kempermann, G.DZNE* ; Takagaki, K. ; Calegari, F.
Author Correction: Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.
Nature Communications 11(1), 1138 (2020) [10.1038/s41467-020-14935-4]2020   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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