Abstract/Journal Article

DZNE-2020-01022

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png M148. Association between Serum Neurofilament Lightand Established White Matter Neuroimaging Markers inAutosomal Dominant Alzheimer Disease

Schultz, S. ; Adedokun, A. ; Strain, J. ; Wang, Q. ; Preische, O.DZNE* ; Kuhle, J. ; Morris, J. ; Bateman, R. ; Jucker, M.DZNE* ; Benzinger, T. ; Gordon, B.

2019

Abstract: Background: White matter (WM) alterations are a commonfeature of Alzheimer Disease (AD), typically detected in vivowith diffusion tensor imaging (DTI). Blood-based neurofila-ment light (NfL) is an emerging biomarker for monitoringneurodegeneration. While NfL is thought to reflect damageto myelinated axons, minimal work has directly examinedthis association. The objective of this study was to examinethe cross-sectional and longitudinal relationship betweenWM neuroimaging markers and serum NfL levels.

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Contributing Institute(s):

1. Cell Biology of Neurologic Diseases (AG Jucker)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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