Journal Article

DZNE-2020-01076

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Executive Function Is Related to the Urinary Urgency in Non-demented Patients With Parkinson’s Disease

Tkaczynska, Z. (First author)DZNE* ; Becker, S.DZNE* ; Maetzler, W. ; Timmers, M. ; Van Nueten, L. ; Sulzer, P.DZNE* ; Salvadore, G. ; Schäffer, E. ; Brockmann, K.DZNE* ; Streffer, J. ; Berg, D.DZNE* ; Liepelt-Scarfone, I. (Last author)DZNE*

2020
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fnagi.2020.00055

Abstract: Introduction: Evidence suggests urinary urgency is associated with cognitive impairment in a subtype of Parkinson’s disease (PD) patients. This study investigates if cognitive impairment independently predicts the presence of urinary dysfunction.Methods: We report data of 189 idiopathic PD patients, excluding those with concomitant diseases or medication interacting with bladder function. A standardized questionnaire was used to define the presence of urinary urgency. All patients underwent a comprehensive motor, cognitive non-motor and health-related quality of life (HRQoL) assessment. Multivariable linear regression analysis was performed to identify independent variables characterizing urinary urgency in PD (PD-UU), which were assigned as discriminant features to estimate their individual contribution to the phenotype of the PD-UU group.Results: Of 189 PD patients, 115 (60.8%) reported PD-UU. The linear regression analysis showed that among cognitive domains, executive function (EF; p = 0.04) had a significant negative association with PD-UU. In a second model, scores of the Montreal Cognitive Assessment (MoCA) significantly differentiated between study groups (p = 0.007) and also non-motor symptom (NMS) burden (p < 0.001). The third model consisted of reports of HRQoL, of which stigma was the only subscale of the Parkinson’s Disease Questionnaire (PDQ-39) differentiating between patients with and without PD-UU (p = 0.02). The linear discriminant analysis provided evidence that the combination of EF, NMS burden, nocturia, and stigma discriminated between groups with 72.4% accuracy.Conclusion: In our large, non-demented PD cohort, urinary urgency was associated with executive dysfunction (EF), supporting a possible causative link between both symptoms. A combination of neuropsychological and non-motor aspects identified patients with PD-UU with high discriminative accuracy.

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Contributing Institute(s):

1. Bonn Pre 2020 (Bonn Pre 2020)
2. Innate Immunity in Neurodegeneration (AG Latz)
3. Parkinson Genetics (AG Gasser 1)
4. Tübingen Pre 2020 (Tübingen Pre 2020)
5. Functional Neurogeriatrics (AG Maetzler)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
3. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2020

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Database coverage:
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