Journal Article

DZNE-2020-01109

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lifetime risk of autosomal recessive mitochondrial disorders calculated from genetic databases

Tan, J. ; Wagner, M. ; Stenton, S. L. ; Strom, T. M. ; Wortmann, S. B. ; Prokisch, H. ; Meitinger, T. ; Oexle, K. ; Klopstock, T. (Last author)DZNE*

2020
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.ebiom.2020.102730

Abstract: BackgroundMitochondrial disorders are a group of rare diseases, caused by nuclear or mitochondrial DNA mutations. Their marked clinical and genetic heterogeneity as well as referral and ascertainment biases render phenotype-based prevalence estimations difficult. Here we calculated the lifetime risk of all known autosomal recessive mitochondrial disorders on basis of genetic data.MethodsWe queried the publicly available Genome Aggregation Database (gnomAD) and our in-house exome database to assess the allele frequency of disease-causing variants in genes associated with autosomal recessive mitochondrial disorders. Based on this, we estimated the lifetime risk of 249 autosomal recessive mitochondrial disorders. Three of these disorders and phenylketonuria (PKU) served as a proof of concept since calculations could be aligned with known birth prevalence data from newborn screening reports.FindingsThe estimated lifetime risks are very close to newborn screening data (where available), supporting the validity of the approach. For example, calculated lifetime risk of PKU (16·0/100,000) correlates well with known birth prevalence data (18·7/100,000). The combined estimated lifetime risk of 249 investigated mitochondrial disorders is 31·8 (20·9–50·6)/100,000 in our in-house database, 48·4 (40·3–58·5)/100,000 in the European gnomAD dataset, and 31·1 (26·7–36·3)/100,000 in the global gnomAD dataset. The disorders with the highest lifetime risk (> 3 per 100,000) were, in all datasets, those caused by mutations in the SPG7, ACADM, POLG and SLC22A5 genes.InterpretationWe provide a population-genetic estimation on the lifetime risk of an entire class of monogenic disorders. Our findings reveal the substantial cumulative prevalence of autosomal recessive mitochondrial disorders, far above previous estimates. These data will be very important for assigning diagnostic a priori probabilities, and for resource allocation in therapy development, public health management and biomedical research.FundingGerman Federal Ministry of Education and Research.

Keyword(s): ATPases Associated with Diverse Cellular Activities: genetics (MeSH) ; Acyl-CoA Dehydrogenase: genetics (MeSH) ; DNA Polymerase gamma: genetics (MeSH) ; Databases, Genetic: statistics & numerical data (MeSH) ; Genes, Recessive (MeSH) ; Genetic Predisposition to Disease (MeSH) ; Humans (MeSH) ; Metalloendopeptidases: genetics (MeSH) ; Mitochondrial Diseases: epidemiology (MeSH) ; Mitochondrial Diseases: genetics (MeSH) ; Solute Carrier Family 22 Member 5: genetics (MeSH)

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Contributing Institute(s):

1. Neuropsychology (AG Wagner)
2. Clinical Neurodegeneration (AG Levin)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 10 ; JCR ; SCOPUS ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Tan, J. ; Wagner, M. ; Stenton, S. L. ; Strom, T. M. ; Wortmann, S. B. ; Prokisch, H. ; Meitinger, T.Extern* ; Oexle, K. ; Klopstock, T. (Last author)DZNE*
Corrigendum to “Lifetime risk of autosomal recessive mitochondrial disorders calculated from genetic databases” [EBioMedicine 54 (2020) 102730]
EBioMedicine 61, 103072 (2020) [10.1016/j.ebiom.2020.103072]2020   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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