Journal Article

DZNE-2020-01310

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reverse engineering synthetic antiviral amyloids.

Michiels, E. ; Roose, K. ; Gallardo, R. ; Khodaparast, L. ; Khodaparast, L. ; van der Kant, R. ; Siemons, M. ; Houben, B. ; Ramakers, M. ; Wilkinson, H. ; Guerreiro, P. ; Louros, N. ; Kaptein, S. J. F. ; Ibañez, L. I. ; Smet, A. ; Baatsen, P. ; Liu, S.DZNE* ; Vorberg, I.DZNE* ; Bormans, G. ; Neyts, J. ; Saelens, X. ; Rousseau, F. (Corresponding author) ; Schymkowitz, J. (Corresponding author)

2020
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-020-16721-8

Abstract: Human amyloids have been shown to interact with viruses and interfere with viral replication. Based on this observation, we employed a synthetic biology approach in which we engineered virus-specific amyloids against influenza A and Zika proteins. Each amyloid shares a homologous aggregation-prone fragment with a specific viral target protein. For influenza we demonstrate that a designer amyloid against PB2 accumulates in influenza A-infected tissue in vivo. Moreover, this amyloid acts specifically against influenza A and its common PB2 polymorphisms, but not influenza B, which lacks the homologous fragment. Our model amyloid demonstrates that the sequence specificity of amyloid interactions has the capacity to tune amyloid-virus interactions while allowing for the flexibility to maintain activity on evolutionary diverging variants.

Keyword(s): Amyloid: genetics (MeSH) ; Amyloid: pharmacology (MeSH) ; Amyloid: therapeutic use (MeSH) ; Animals (MeSH) ; Antiviral Agents: pharmacology (MeSH) ; Antiviral Agents: therapeutic use (MeSH) ; Disease Models, Animal (MeSH) ; Dogs (MeSH) ; Female (MeSH) ; HEK293 Cells (MeSH) ; Host-Pathogen Interactions: drug effects (MeSH) ; Humans (MeSH) ; Influenza A virus: drug effects (MeSH) ; Influenza A virus: genetics (MeSH) ; Influenza A virus: pathogenicity (MeSH) ; Influenza, Human: drug therapy (MeSH) ; Influenza, Human: virology (MeSH) ; Madin Darby Canine Kidney Cells (MeSH) ; Mice (MeSH) ; Polymorphism, Genetic (MeSH) ; Recombinant Proteins: genetics (MeSH) ; Recombinant Proteins: pharmacology (MeSH) ; Recombinant Proteins: therapeutic use (MeSH) ; Reverse Genetics: methods (MeSH) ; Synthetic Biology: methods (MeSH) ; Viral Proteins: genetics (MeSH) ; Viral Proteins: metabolism (MeSH) ; Virus Replication: drug effects (MeSH) ; Zika Virus: drug effects (MeSH) ; Zika Virus: genetics (MeSH) ; Zika Virus: pathogenicity (MeSH) ; Zika Virus Infection: drug therapy (MeSH) ; Zika Virus Infection: virology (MeSH) ; Amyloid ; Antiviral Agents ; Recombinant Proteins ; Viral Proteins

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Contributing Institute(s):

1. Prion Cell Biology (AG Vorberg)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Michiels, E. ; Roose, K. ; Gallardo, R. ; Khodaparast, L. ; Khodaparast, L. ; van der Kant, R. ; Siemons, M. ; Houben, B. ; Ramakers, M. ; Wilkinson, H. ; Guerreiro, P. ; Louros, N. ; Kaptein, S. J. F. ; Ibañez, L. I. ; Smet, A. ; Baatsen, P. ; Liu, S.DZNE* ; Vorberg, I.DZNE* ; Bormans, G. ; Neyts, J. ; Saelens, X. ; Rousseau, F. ; Schymkowitz, J.
Author Correction: Reverse engineering synthetic antiviral amyloids.
Nature Communications 14(1), 3492 (2023) [10.1038/s41467-023-39293-9]2023   Files  Fulltext Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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