Journal Article

DZNE-2021-00113

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png FDG-PET hypermetabolism is associated with higher tau-PET in mild cognitive impairment at low amyloid-PET levels.

Rubinski, A. ; Franzmeier, N. ; Neitzel, J. ; Ewers, M. (Corresponding author)DZNE* ; Initiative, A. D. N. (Collaboration Author)

2020
BioMed Central London

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Please use a persistent id in citations: doi:10.1186/s13195-020-00702-6

Abstract: FDG-PET hypermetabolism can be observed in mild cognitive impairment (MCI), but the link to primary pathologies of Alzheimer's diseases (AD) including amyloid and tau is unclear.Using voxel-based regression, we assessed local interactions between amyloid- and tau-PET on spatially matched FDG-PET in 72 MCI patients. Control groups included cerebrospinal fluid biomarker characterized cognitively normal (CN, n = 70) and AD dementia subjects (n = 95).In MCI, significant amyloid-PET by tau-PET interactions were found in frontal, lateral temporal, and posterior parietal regions, where higher local tau-PET was associated with higher spatially corresponding FDG-PET at low levels of local amyloid-PET. FDG-PET in brain regions with a significant local amyloid- by tau-PET interaction was higher compared to that in CN and AD dementia and associated with lower episodic memory.Higher tau-PET in the presence of low amyloid-PET is associated with abnormally increased glucose metabolism that is accompanied by episodic memory impairment.

Keyword(s): Alzheimer Disease: diagnostic imaging (MeSH) ; Amyloid (MeSH) ; Amyloid beta-Peptides (MeSH) ; Cognitive Dysfunction: diagnostic imaging (MeSH) ; Fluorodeoxyglucose F18 (MeSH) ; Humans (MeSH) ; Positron-Emission Tomography (MeSH) ; tau Proteins (MeSH) ; Amyloid-PET ; FDG-PET ; Hyperactivation ; Hypermetabolism ; Mild cognitive impairment ; Tau-PET

Note: ISSN 1758-9193 not unique: **3 hits**.

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Contributing Institute(s):

1. Molecular Neurobiology (AG Simons)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2020

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