Journal Article

DZNE-2021-00990

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.

Meinhardt, J. ; Radke, J. ; Dittmayer, C. ; Franz, J. ; Thomas, C. ; Mothes, R. ; Laue, M. ; Schneider, J. ; Brünink, S. ; Greuel, S. ; Lehmann, M. ; Hassan, O. ; Aschman, T. ; Schumann, E. ; Chua, R. L. ; Conrad, C. ; Eils, R. ; Stenzel, W. ; Windgassen, M. ; Rößler, L. ; Goebel, H.-H. ; Gelderblom, H. R. ; Martin, H. ; Nitsche, A. ; Schulz-Schaeffer, W. J. ; Hakroush, S. ; Winkler, M. S. ; Tampe, B. ; Scheibe, F.Extern* ; Körtvélyessy, P.DZNE* ; Reinhold, D. ; Siegmund, B. ; Kühl, A. A. ; Elezkurtaj, S. ; Horst, D. ; Oesterhelweg, L. ; Tsokos, M. ; Ingold-Heppner, B. ; Stadelmann, C.Extern* ; Drosten, C. ; Corman, V.Extern* ; Radbruch, H. ; Heppner, F. (Last author)DZNE*

2021
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41593-020-00758-5

Abstract: The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events throughout the body, including in the CNS, have been described. Given the neurological symptoms observed in a large majority of individuals with COVID-19, SARS-CoV-2 penetrance of the CNS is likely. By various means, we demonstrate the presence of SARS-CoV-2 RNA and protein in anatomically distinct regions of the nasopharynx and brain. Furthermore, we describe the morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and present evidence of SARS-CoV-2 neurotropism. SARS-CoV-2 can enter the nervous system by crossing the neural-mucosal interface in olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue, including delicate olfactory and sensory nerve endings. Subsequently, SARS-CoV-2 appears to follow neuroanatomical structures, penetrating defined neuroanatomical areas including the primary respiratory and cardiovascular control center in the medulla oblongata.

Keyword(s): Brain: virology (MeSH) ; COVID-19: virology (MeSH) ; Central Nervous System (MeSH) ; Humans (MeSH) ; Olfactory Mucosa: virology (MeSH) ; RNA, Viral: genetics (MeSH) ; SARS-CoV-2: pathogenicity (MeSH) ; Smell: physiology (MeSH) ; Virus Internalization (MeSH) ; RNA, Viral

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Contributing Institute(s):

1. Neuroimmunology (AG Heppner)
2. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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