Journal Article (Review Article)

DZNE-2022-00399

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Animal Models of Neointimal Hyperplasia and Restenosis: Species-Specific Differences and Implications for Translational Research.

Ebert, M. L. A. ; Schmidt, V. F. ; Pfaff, L. ; von Thaden, A.DZNE* ; Kimm, M. A. ; Wildgruber, M.

2021
American College of Cardiology Washington, DC

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Please use a persistent id in citations: doi:10.1016/j.jacbts.2021.06.006

Abstract: The process of restenosis is based on the interplay of various mechanical and biological processes triggered by angioplasty-induced vascular trauma. Early arterial recoil, negative vascular remodeling, and neointimal formation therefore limit the long-term patency of interventional recanalization procedures. The most serious of these processes is neointimal hyperplasia, which can be traced back to 4 main mechanisms: endothelial damage and activation; monocyte accumulation in the subintimal space; fibroblast migration; and the transformation of vascular smooth muscle cells. A wide variety of animal models exists to investigate the underlying pathophysiology. Although mouse models, with their ease of genetic manipulation, enable cell- and molecular-focused fundamental research, and rats provide the opportunity to use stent and balloon models with high throughput, both rodents lack a lipid metabolism comparable to humans. Rabbits instead build a bridge to close the gap between basic and clinical research due to their human-like lipid metabolism, as well as their size being accessible for clinical angioplasty procedures. Every different combination of animal, dietary, and injury model has various advantages and disadvantages, and the decision for a proper model requires awareness of species-specific biological properties reaching from vessel morphology to distinct cellular and molecular features.

Keyword(s): Apo, apolipoprotein ; CETP, cholesteryl ester transferase protein ; ECM, extracellular matrix ; FGF, fibroblast growth factor ; HDL, high-density lipoprotein ; LDL, low-density lipoprotein ; LDLr, LDL receptor ; PDGF, platelet-derived growth factor ; TGF, transforming growth factor ; VLDL, very low-density lipoprotein ; VSMC, vascular smooth muscle cell ; angioplasty ; animal model ; neointimal hyperplasia ; restenosis

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Contributing Institute(s):

1. Animal Facility (Mouse) (Animal Facility (Mouse) München)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2021

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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