Contribution to a book

DZNE-2022-01707

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease.

Kaniyappan, S. (First author)DZNE* ; Balaji, V.DZNE* ; Wang, Y.DZNE* ; Mandelkow, E. (Last author)DZNE*

2023
Springer US New York, NY
ISBN: 978-1-0716-2596-5 (print), 978-1-0716-2597-2 (electronic)

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Please use a persistent id in citations: doi:10.1007/978-1-0716-2597-2_9

Abstract: Tau is a microtubule-associated protein found mainly in the axons of neurons in the brain. Abnormal changes in Tau (e.g., aggregation, hyperphosphorylation) are hallmarks of Alzheimer's disease. Two processes of relocalization of Tau may be related to early states of the pathology and have received much attention: (1) the redistribution of Tau within cells (termed 'somatodendritic missorting') and (2) the release and reuptake of Tau from donor to acceptor cells (termed 'spreading'). Because of the tripartite nature of neurons (cell body, dendrites, axons), these changes can be studied by microfluidic chambers (MFCs) which allow separation and observation of Tau in neuronal compartments. In this chapter, we present some methods and research results obtained by using microfluidic devices.

Keyword(s): Humans (MeSH) ; tau Proteins: metabolism (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Microfluidics (MeSH) ; Neurons: metabolism (MeSH) ; Axons: metabolism (MeSH) ; Microfluidic chambers ; Missorting ; Primary neurons ; Spreading ; Tau ; tau Proteins

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Contributing Institute(s):

1. Structural Principles of Neurodegeneration (AG Mandelkow 1)
2. Cell and Animal Models of Neurodegeneration (AG Mandelkow 2)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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Database coverage:
; SCOPUS

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