Journal Article (Review Article)

DZNE-2023-00555

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Insights and opportunities for deep brain stimulation as a brain circuit intervention.

Neumann, W.-J. ; Horn, A. ; Kühn, A. A. (Last author)DZNE*

2023
Elsevier Science Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.tins.2023.03.009

Abstract: Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into the dynamic circuit architecture of brain disorders. This Review illustrates our current understanding of the pathophysiology of movement disorders and their underlying brain circuits that are modulated with DBS. It proposes principles of pathological network synchronization patterns like beta activity (13-35 Hz) in Parkinson's disease. We describe alterations from microscale including local synaptic activity via modulation of mesoscale hypersynchronization to changes in whole-brain macroscale connectivity. Finally, an outlook on advances for clinical innovations in next-generation neurotechnology is provided: from preoperative connectomic targeting to feedback controlled closed-loop adaptive DBS as individualized network-specific brain circuit interventions.

Keyword(s): Humans (MeSH) ; Deep Brain Stimulation (MeSH) ; Parkinson Disease: therapy (MeSH) ; Brain (MeSH) ; Connectome (MeSH) ; brain–computer interface ; brain–computer interface ; brain–computer interface ; brain–computer interface ; connectomics ; electrocorticography ; local field potentials ; movement disorders ; neurophysiology

---

Contributing Institute(s):

1. Clinical Study Team Berlin Kühn (Clinical Study Team Berlin 2 ; AG Kühn)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

---

Database coverage:
; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---