Journal Article

DZNE-2023-00560

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CSF oligoclonal IgG bands are not associated with ALS progression and prognosis.

Klose, V.-F. (First author)DZNE* ; Jesse, S.DZNE* ; Lewerenz, J. ; Kassubek, J.DZNE* ; Dorst, J.DZNE* ; Tumani, H.DZNE* ; Ludolph, A. C.DZNE* ; Roselli, F. (Last author)DZNE*

2023
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fneur.2023.1170360

Abstract: Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.IgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively collected in the Register Schabia.The prevalence of IgG OCB is comparable in ALS and the four neurological cohorts. When the OCB pattern was considered (highlighting either intrathecal or systemic B-cells activation), no effect of OCB pattern on clinic-demographic parameters and overall. ALS patients with intrathecal IgG synthesis (type 2 and 3) were more likely to display infectious, inflammatory or systemic autoimmune conditions.These data suggest that OCB are not related to ALS pathophysiology but rather are a finding possibly indicative a coincidental infectious or inflammatory comorbidity that merits further investigation.

Keyword(s): age of onset ; amyotrophic lateral sclerosis ; cerebrospinal fluid ; intrathecal synthesis ; oligoclonal bands ; survival

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Contributing Institute(s):

1. Metabolic Changes (AG Roselli)
2. Neuroepidemiology (AG Zhan ; AG Zhan)
3. Clinical Study Center Ulm (Clinical Study Center ; Clinical Study Center Ulm)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)
2. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)
3. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2023

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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