Journal Article

DZNE-2024-00343

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lifelong persistence of nuclear RNAs in the mouse brain.

Zocher, S. (First author)DZNE* ; McCloskey, A. ; Karasinsky, A.DZNE* ; Schulte, R. ; Friedrich, U. ; Lesche, M. ; Rund, N.DZNE* ; Gage, F. H. ; Hetzer, M. W. ; Toda, T. (Last author)DZNE*

2024
American Association for the Advancement of Science Washington, DC

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Please use a persistent id in citations: doi:10.1126/science.adf3481

Abstract: Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type-specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.

Keyword(s): Animals (MeSH) ; Mice (MeSH) ; Brain: metabolism (MeSH) ; Chromatin (MeSH) ; Gene Expression Regulation (MeSH) ; Heterochromatin: genetics (MeSH) ; RNA, Nuclear: genetics (MeSH) ; Chromatin ; Heterochromatin ; RNA, Nuclear

Note: ISSN 1095-9203 not unique: **3 hits**.

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Contributing Institute(s):

1. Nuclear Architecture in Neural Plasticity and Aging (AG Toda)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 50 ; Index Chemicus ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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