Journal Article

DZNE-2024-00464

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png A hippocampus-accumbens code guides goal-directed appetitive behavior.

Barnstedt, O. (First author)DZNE* ; Mocellin, P.Extern* ; Remy, S. (Last author)DZNE*

2024
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-024-47361-x

Abstract: The dorsal hippocampus (dHPC) is a key brain region for the expression of spatial memories, such as navigating towards a learned reward location. The nucleus accumbens (NAc) is a prominent projection target of dHPC and implicated in value-based action selection. Yet, the contents of the dHPC→NAc information stream and their acute role in behavior remain largely unknown. Here, we found that optogenetic stimulation of the dHPC→NAc pathway while mice navigated towards a learned reward location was both necessary and sufficient for spatial memory-related appetitive behaviors. To understand the task-relevant coding properties of individual NAc-projecting hippocampal neurons (dHPC→NAc), we used in vivo dual-color two-photon imaging. In contrast to other dHPC neurons, the dHPC→NAc subpopulation contained more place cells, with enriched spatial tuning properties. This subpopulation also showed enhanced coding of non-spatial task-relevant behaviors such as deceleration and appetitive licking. A generalized linear model revealed enhanced conjunctive coding in dHPC→NAc neurons which improved the identification of the reward zone. We propose that dHPC routes specific reward-related spatial and behavioral state information to guide NAc action selection.

Keyword(s): Animals (MeSH) ; Mice (MeSH) ; Goals (MeSH) ; Hippocampus (MeSH) ; Appetitive Behavior (MeSH) ; Spatial Memory (MeSH) ; Phospholipid Ethers (MeSH) ; 1,2-dihexadecyl-sn-glycero-3-phosphocholine ; Phospholipid Ethers

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Contributing Institute(s):

1. Neuronal Networks (AG Remy)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2024

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