Journal Article (Review Article)

DZNE-2024-00470

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png NLRP3 inflammasome signalling in Alzheimer's disease

McManus, R. M. (First author)DZNE* ; Latz, E.Extern*

2024
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.neuropharm.2024.109941

Abstract: Every year, 10 million people develop dementia, the most common of which is Alzheimer's disease (AD). To date, there is no way to prevent cognitive decline and therapies are limited. This review provides a neuroimmunological perspective on the progression of AD, and discusses the immune-targeted therapies that are in preclinical and clinical trials that may impact the development of this disease. Specifically, we look to the role of the NLRP3 inflammasome, its triggers in the brain and how its activation can contribute to the progression of dementia. We summarise the range of inhibitors targeting the NLRP3 inflammasome and its downstream pathways that are under investigation, and discuss future therapeutic perspectives for this devastating condition.

Keyword(s): Animals (MeSH) ; Humans (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Alzheimer Disease: immunology (MeSH) ; Alzheimer Disease: drug therapy (MeSH) ; Brain: metabolism (MeSH) ; Brain: immunology (MeSH) ; Inflammasomes: metabolism (MeSH) ; NLR Family, Pyrin Domain-Containing 3 Protein: metabolism (MeSH) ; NLR Family, Pyrin Domain-Containing 3 Protein: antagonists & inhibitors (MeSH) ; Signal Transduction: physiology (MeSH) ; Signal Transduction: drug effects (MeSH) ; Alzheimer's disease ; Immune-targeted therapies ; Microglia ; NLRP3 inflammasome ; Neuroimmunology ; Preclinical models ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz ; AG Latz)
2. Translational Neuroimmunology (AG McManus)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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