Journal Article

DZNE-2024-01167

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Protective lifelines: Tunneling nanotubes connect neurons and microglia.

Neher, J. J. (First author)DZNE* ; Simons, M. (Last author)DZNE*

2024
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.neuron.2024.07.027

Abstract: Tunneling nanotubes (TNTs) facilitate the exchange of intracellular cargo between cells. In this issue of Neuron, Scheiblich et al.1 reveal that TNTs selectively mediate the bidirectional transfer of cytoplasmic protein aggregates from neurons to microglia and mitochondria from microglia to neurons, thereby preserving neuronal health.

Keyword(s): Microglia: metabolism (MeSH) ; Neurons: metabolism (MeSH) ; Animals (MeSH) ; Humans (MeSH) ; Nanotubes (MeSH) ; Cell Communication: physiology (MeSH) ; Mitochondria: metabolism (MeSH) ; Cell Membrane Structures (MeSH) ; Tunneling Nanotubes

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Contributing Institute(s):

1. Molecular Neurobiology (AG Simons)
2. Clinical Research (Munich) (Clinical Research (Munich))
3. Neuroimmunology and Neurodegenerative Disease (AG Neher (München))

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
3. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Scheiblich, H. (First author)DZNE* ; Eikens, F.DZNE* ; Wischhof, L.DZNE* ; Opitz, S. ; Jüngling, K. ; Cserép, C. ; Schmidt, S. V. ; Lambertz, J. ; Bellande, T. ; Pósfai, B. ; Geck, C. ; Spitzer, J. ; Odainic, A. ; Castro-Gomez, M. S.Extern* ; Schwartz, S. ; Boussaad, I. ; Krüger, R. ; Glaab, E. ; Di Monte, D. A.DZNE* ; Bano, D.DZNE* ; Dénes, Á. ; Latz, E.DZNE* ; Melki, R. ; Pape, H.-C. ; Heneka, M. T. (Last author)DZNE*
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes.
Neuron 112(18), 3106 - 3125.e8 (2024) [10.1016/j.neuron.2024.06.029]2024   Files BibTeX | EndNote: XML, Text | RIS

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