Journal Article (Review Article)

DZNE-2024-01374

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Systematic review-based guideline 'Parkinson's disease' of the German Society of Neurology: diagnostic use of transcranial sonography.

Walter, U. (First author)DZNE* ; Loewenbrück, K. F. ; Dodel, R. ; Storch, A.DZNE* ; Trenkwalder, C. ; Höglinger, G. (Last author)DZNE* ; Group, G. P. G. (Collaboration Author)

2024
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00415-024-12502-1

Abstract: Transcranial brain parenchyma sonography (TCS) has been recommended as a tool for the early and differential diagnosis of Parkinson's disease (PD) in German and European clinical guidelines. Still, the brain structures to be examined for the diagnostic questions and the requirements for being a qualified investigator were not specified in detail. These issues have now been addressed in the 2023 update of the clinical guideline on PD by the German Society of Neurology (DGN).The recommendations were based on a systematic literature review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.Three diagnostic questions were defined: (1) What is the accuracy of TCS in the differential diagnosis of PD versus atypical and secondary Parkinsonian syndromes? (2) What is the accuracy of TCS in the differential diagnosis of PD versus essential tremor? (3) What is the accuracy of TCS in the diagnosis of PD in persons with typical early symptoms, compared with the diagnosis established by clinical follow-up? The brain structures to be assessed and the level of recommendation were formulated for these questions. The training requirements for being regarded as qualified TCS investigator were stipulated by the responsible medical societies (German Society of Ultrasound in Medicine, DEGUM; German Society for Clinical Neurophysiology and Functional Imaging, DGKN). Finally, the recommendations for these diagnostic questions reached strong consensus (each ≥ 97%) of the guideline committee. Here, the details of review and recommendations are presented.The updated guideline clarifies the diagnostic uses and limitations of TCS in PD.

Keyword(s): Humans (MeSH) ; Parkinson Disease: diagnostic imaging (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Ultrasonography, Doppler, Transcranial: standards (MeSH) ; Ultrasonography, Doppler, Transcranial: methods (MeSH) ; Neurology: standards (MeSH) ; Germany (MeSH) ; Societies, Medical: standards (MeSH) ; Practice Guidelines as Topic: standards (MeSH) ; Diagnosis, Differential (MeSH) ; Essential tremor ; Neuroimaging ; Parkinsonism ; Parkinson’s disease ; Systematic review ; Transcranial ultrasound

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Contributing Institute(s):

1. Clinical Research (Munich) (Clinical Research (Munich))
2. Non-Motor Symptoms in Parkinson's disease (AG Storch)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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