Journal Article

DZNE-2024-01414

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Blood-CSF barrier integrity in amyotrophic lateral sclerosis.

Klose, V. (First author)DZNE* ; Jesse, S.DZNE* ; Lewerenz, J. ; Kassubek, J.DZNE* ; Dorst, J.Extern* ; Rosenbohm, A. ; Nagel, G. ; Wernecke, D. ; Roselli, F.DZNE* ; Tumani, H.Extern* ; Ludolph, A. C. (Last author)DZNE*

2024
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/brain/awae144

Abstract: The integrity of the blood-CSF barrier plays a major role in inflammation, but also in shielding the CNS from external and systemic-potentially toxic-factors. Here we report results of measurements of the albumin quotient-which is thought to mirror the integrity of the blood-CSF barrier-in 1059 patients with amyotrophic lateral sclerosis. The results were compared with groups of patients suffering from Alzheimer's disease, facial palsy and tension headache. The albumin quotient, an accepted measure of the blood-CSF barrier integrity, was not significantly different from control populations. In addition, we found that the albumin quotient correlated with survival of the patients; this effect was mainly driven by male patients and influenced by age, body mass index and diabetes mellitus. We conclude that the blood-CSF barrier is intact in this large cohort of patients with amyotrophic lateral sclerosis and that the albumin quotient correlates with survival. Whether this is important for the pathogenesis of the disease, requires mechanistic studies.

Keyword(s): Humans (MeSH) ; Amyotrophic Lateral Sclerosis (MeSH) ; Male (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Aged (MeSH) ; Blood-Brain Barrier: metabolism (MeSH) ; Adult (MeSH) ; Albumins: metabolism (MeSH) ; Aged, 80 and over (MeSH) ; Cohort Studies (MeSH) ; albumin quotient ; amyotrophic lateral sclerosis ; blood-CSF barrier ; cerebrospinal fluid ; survival ; Albumins

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Contributing Institute(s):

1. Clinical Study Center (Ulm) (Clinical Study Center (Ulm))
2. Neuroepidemiology (AG Zhan)
3. Metabolic Changes in Neurodegeneration (AG Roselli)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)
3. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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