Journal Article

DZNE-2025-00032

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The role of leukocytes in cognitive impairment due to long-term exposure to fine particulate matter: A large population-based mediation analysis.

Aretz, B. ; Doblhammer, G.DZNE* ; Heneka, M.Extern*

2024
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.14320

Abstract: Our understanding of how fine particulate matter (PM2.5) impacts cognitive functioning is limited. Systemic inflammation processes may play a role in mediating this effect.This prospective cohort study used data from 66,254 participants aged 18+ between 2006 and 2015 from the Dutch Lifelines Cohort Study and Biobank. Causal mediation analysis was conducted to examine the impact of ambient PM2.5 exposure on cognitive processing time (CPT), using the change in white blood cell (WBC) count and its subtypes as potential mediators.Heightened PM2.5 exposure was associated with slower CPT (total effect = 81.76 × 10-3, 95% confidence interval [CI] 59.51 × 10-3-105.31 × 10-3). The effect was partially mediated via increased WBC count (indirect effect [IE] = 0.42 × 10-3, 95% CI 0.07 × 10-3-0.90 × 10-3), particularly driven by an increase in monocytes (IE = 0.73 × 10-3, 95% CI 0.24 × 10-3-1.31 × 10-3).Systemic inflammation processes may partially explain the harmful effects of PM2.5 on cognitive functioning, why lower levels of systemic inflammation may help contain its neurotoxic effects.The pathways leading to the neurotoxic effects of fine particulate matter (PM2.5) are poorly understood. We analyzed data from over 66,000 participants using causal pathway analysis. Increased white blood cell (WBC) count mediates the effect of PM2.5 on cognitive functioning. Monocyte count played a crucial role in this low-pollution setting. Systemic inflammation may contribute to the neurotoxic effects of PM2.5.

Keyword(s): Humans (MeSH) ; Particulate Matter: adverse effects (MeSH) ; Male (MeSH) ; Female (MeSH) ; Cognitive Dysfunction (MeSH) ; Prospective Studies (MeSH) ; Middle Aged (MeSH) ; Mediation Analysis (MeSH) ; Leukocytes: drug effects (MeSH) ; Environmental Exposure: adverse effects (MeSH) ; Netherlands: epidemiology (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Inflammation (MeSH) ; Leukocyte Count (MeSH) ; Air Pollution: adverse effects (MeSH) ; Air Pollution: statistics & numerical data (MeSH) ; Cohort Studies (MeSH) ; Air Pollutants: adverse effects (MeSH) ; causal mediation analysis ; cognitive functioning ; fine particulate matter ; leukocytes ; systemic inflammation ; white blood cell count ; Particulate Matter ; Air Pollutants

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Contributing Institute(s):

1. Demographic Studies (AG Doblhammer)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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