Journal Article

DZNE-2025-00745

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Diffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy.

Barlescu, L.Extern* ; Höglinger, G. U.DZNE* ; Volkmann, H. ; Ludolph, A. C.DZNE* ; Del Tredici, K. ; Braak, H. ; Müller, H.-P. ; Kassubek, J.Extern* ; Group, D. S. (Collaboration Author) ; Brandt, M. (Contributor)Extern* ; Bürger, K. (Contributor)Extern* ; Düzel, E. (Contributor)Extern* ; Falkenburger, B. (Contributor)Extern* ; Flöel, A. (Contributor)Extern* ; Glanz, W. (Contributor)Extern* ; Höglinger, G. (Contributor)Extern* ; Janowitz, D. (Contributor)Extern* ; Katzdobler, S. (Contributor)Extern* ; Kilimann, I. (Contributor)Extern* ; Kimmich, O. (Contributor)Extern* ; Levin, J. (Contributor)Extern* ; Peters, O. (Contributor)Extern* ; Priller, J. (Contributor)Extern* ; Prudlo, J. (Contributor)Extern* ; Schneider, L.-S. (Contributor)Extern* ; Spottke, A. (Contributor)Extern* ; Spruth, E. J. (Contributor) ; Synofzik, M. (Contributor)Extern* ; Teipel, S. (Contributor)Extern* ; Wilke, C. (Contributor)Extern*

2025
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fnagi.2025.1569302

Abstract: A neuropathological cerebral staging concept for progressive supranuclear palsy (PSP) has been proposed that tau inclusions in PSP may progress in a sequential regional pattern. The objective was to develop a hypothesis-guided region/tract of interest-based (ROI/TOI) approach to use diffusion tensor imaging (DTI) targeted to analyze in vivo the regions that are prone to be involved at each neuropathological stage of PSP.Two data cohorts were analyzed: cohort A of 78 PSP patients [55 Richardson's syndrome (PSP-RS) and 23 PSP with predominant parkinsonism (PSP-P)] and 63 controls, recorded at 3.0T at multiple sites, and a single-site cohort B constituted by 1.5T data of 66 PSP patients (46 PSP-RS and 20 PSP-P) and 44 controls. In cohort A, 21 PSP patients (13 PSP-RS and 8 PSP-P) and 17 controls obtained a follow-up scan after 17 months. Whole brain-based spatial statistics (WBSS) was used to identify the alterations in PSP patients vs. controls. The combined ROI- and TOI-based approach targeted structures that are prone to be involved during the course of PSP.WBSS demonstrated alterations predominantly in brainstem/midbrain, basal ganglia, and frontal lobe, more pronounced in the longitudinal data. Statistical analyses of the ROIs/TOIs showed a sequential pattern of structures that were assigned to previously defined neuropathological steps.The combined ROI- and TOI-based DTI approach was able to map the disease stages of PSP in vivo cross-sectionally and longitudinally, lending support to DTI as a technical marker for imaging disease progression according to PSP stages. This approach might be useful as a tool for stratification of PSP patients MRI with respect to its proposed neuropathological progression in future longitudinal and autopsy-controlled studies.

Keyword(s): diffusion tensor imaging (DTI) ; neuropathology ; progressive supranuclear palsy ; sequential pattern ; tau protein

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Contributing Institute(s):

1. Clinical Research (Munich) (Clinical Research (Munich))
2. Clinical Study Center (Ulm) (Clinical Study Center (Ulm))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Experiment(s):

1. DZNE Clinical Registry Study of Neurodegenerative Diseases in Patients with Progressive Supranuclear Paresis (PSP)

Appears in the scientific report 2025

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