Journal Article

DZNE-2025-00847

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking.

Cooper, C. ; Parthier, D. ; Sibille, J. ; Tukker, J. J.DZNE* ; Tritsch, N. ; Schmitz, D. (Last author)DZNE*

2025
eLife Sciences Publications Cambridge

This record in other databases:  

Please use a persistent id in citations: doi:10.7554/eLife.101105

Abstract: Beyond the vast array of functional roles attributed to serotonin (5-HT) in the brain, changes in 5-HT levels have been shown to accompany changes in behavioral states, including WAKE, NREM, and REM sleep. Whether 5-HT dynamics at shorter time scales can be seen to delineate substates within these larger brain states remains an open question. Here, we performed simultaneous recordings of extracellular 5-HT using a recently developed G-Protein-Coupled Receptor-Activation-Based 5-HT sensor (GRAB5-HT3.0) and local field potential in the hippocampal CA1 of mice, which revealed the presence of prominent ultraslow (<0.05 Hz) 5-HT oscillations both during NREM and WAKE states. Interestingly, the phase of these ultraslow 5-HT oscillations was found to distinguish substates both within and across larger behavioral states. Hippocampal ripples occurred preferentially on the falling phase of ultraslow 5-HT oscillations during both NREM and WAKE, with higher power ripples concentrating near the peak specifically during NREM. By contrast, hippocampal-cortical coherence was strongest, and microarousals and intracranial EMG peaks were most prevalent during the rising phase in both wake and NREM. Overall, ultraslow 5-HT oscillations delineate substates within the larger behavioral states of NREM and WAKE, thus potentially temporally segregating internal memory consolidation processes from arousal-related functions.

Keyword(s): Animals (MeSH) ; Serotonin: metabolism (MeSH) ; Wakefulness: physiology (MeSH) ; Mice (MeSH) ; Hippocampus: physiology (MeSH) ; Male (MeSH) ; Mice, Inbred C57BL (MeSH) ; CA1 Region, Hippocampal: physiology (MeSH) ; Sleep (MeSH) ; behavioral state ; hippocampus ; mouse ; neuroscience ; oscillation ; ripples ; serotonin ; Serotonin

---

Contributing Institute(s):

1. Network Dysfunction (AG Schmitz)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2025

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---