Journal Article (Review Article)

DZNE-2025-00906

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lipid metabolism and neuroinflammation: What is the link?

Tiwari, V. (First author)DZNE* ; Simons, M. (Last author)DZNE*

2025
Rockefeller Univ. Press New York, NY

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Please use a persistent id in citations: doi:10.1084/jem.20241232

Abstract: Lipid metabolism is central to host defense by supporting and modulating immune cell function. Immune signaling pathways control anabolic lipid processes to drive membrane synthesis and produce bioactive lipid mediators during activation. In turn, metabolic states profoundly influence immune signaling, particularly during the resolution of inflammation. Emerging evidence highlights a dynamic interplay between lipid metabolism and neuroinflammation. A striking example is the intrinsic lipoprotein system of the central nervous system, which undergoes profound changes during pathology, with lipoproteins serving not only in lipid transport but also as immune modulators and as contributors to disease tolerance. Importantly, major neurodegenerative diseases are genetically linked to disruptions in lipid metabolism. Deciphering this complex cross talk may provide opportunities for novel therapies targeting neuroinflammatory and neurodegenerative disorders.

Keyword(s): Humans (MeSH) ; Lipid Metabolism (MeSH) ; Animals (MeSH) ; Neuroinflammatory Diseases: metabolism (MeSH) ; Neuroinflammatory Diseases: immunology (MeSH) ; Neuroinflammatory Diseases: pathology (MeSH) ; Inflammation: metabolism (MeSH) ; Neurodegenerative Diseases: metabolism (MeSH) ; Neurodegenerative Diseases: immunology (MeSH) ; Neurodegenerative Diseases: pathology (MeSH) ; Signal Transduction (MeSH) ; Lipoproteins: metabolism (MeSH) ; Central Nervous System: metabolism (MeSH) ; Central Nervous System: immunology (MeSH) ; Lipoproteins

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Contributing Institute(s):

1. Molecular Neurobiology (AG Simons)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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