Axon initial segment dynamics during associative fear learning

Benoit, Chloé Maëlle; Sattin, Andrea; Fellin, Tommaso; Thome, Christian; Engelhardt, Maren; Esser, Julia; Gründemann, Jan; Innocenti, Sabrina Milena; Lüthi, Andreas; Janssen, Jan Maximilian; Paricio-Montesinos, Ricardo; Ganea, Dan Alin; Krabbe, Sabine

doi:10.1038/s41593-025-02152-5

Journal Article

DZNE-2026-00034

Axon initial segment dynamics during associative fear learning

Benoit, C. M. (First author)DZNE* ; Ganea, D. A. (First author)DZNE* ; Paricio-Montesinos, R.DZNE* ; Esser, J.DZNE* ; Thome, C. ; Janssen, J. M. ; Sattin, A. ; Innocenti, S. M. ; Krabbe, S.DZNE* ; Lüthi, A. ; Fellin, T. ; Engelhardt, M. ; Gründemann, J. (Last author)DZNE*

2026
Nature America New York, NY

Nature neuroscience 29(3), 535 - 542 (2026) [10.1038/s41593-025-02152-5]

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Please use a persistent id in citations: doi:10.1038/s41593-025-02152-5

Abstract: The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.

Keyword(s): Animals (MeSH) ; Fear: physiology (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Prefrontal Cortex: cytology (MeSH) ; Axon Initial Segment: physiology (MeSH) ; Neuronal Plasticity: physiology (MeSH) ; Extinction, Psychological: physiology (MeSH) ; Association Learning: physiology (MeSH) ; Mice, Inbred C57BL (MeSH) ; Axons: physiology (MeSH) ; Mice, Transgenic (MeSH) ; Action Potentials: physiology (MeSH)

Classification:

ddc:610

Contributing Institute(s):

Research Program(s):

351 - Brain Function (POF4-351) (POF4-351)

Experiment(s):

Light Microscope Facility (CRFS-LMF) / Bonn

Database coverage:
Medline

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