Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation.

Leiter, Odette; Walker, Tara; Overall, Rupert W; Ramasz, Beáta; Schallenberg, Sonja; Rund, Nicole; Kempermann, Gerd; Seidemann, Suse; Grinenko, Tatyana; Wielockx, Ben

doi:10.1016/j.stemcr.2019.02.009

Journal Article

DZNE-2020-06952

Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation.

Leiter, O. (First author)DZNE* ; Seidemann, S. ; Overall, R. W.DZNE* ; Ramasz, B. ; Rund, N.DZNE* ; Schallenberg, S. ; Grinenko, T. ; Wielockx, B. ; Kempermann, G.DZNE* ; Walker, T. (Last author)DZNE*

2019
Elsevier [New York, NY]

Stem cell reports 12(4), 667-679 (2019) [10.1016/j.stemcr.2019.02.009]

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Abstract: Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved. Here we show that platelets are activated after acute periods of running, and that activated platelets promote neurogenesis, an effect that is likely mediated by platelet factor 4. Ex vivo, the beneficial effects of activated platelets and platelet factor 4 on neural precursor cells were dentate gyrus specific and not observed in the subventricular zone. Moreover, the depletion of circulating platelets in mice abolished the running-induced increase in precursor cell proliferation in the dentate gyrus following exercise. These findings demonstrate that platelets and their released factors can modulate adult neural precursor cells under physiological conditions and provide an intriguing link between running-induced platelet activation and the modulation of neurogenesis after exercise.

Keyword(s): Animals (MeSH) ; Blood Platelets: metabolism (MeSH) ; Cell Proliferation (MeSH) ; Dentate Gyrus: metabolism (MeSH) ; Hippocampus: metabolism (MeSH) ; Mice (MeSH) ; Neural Stem Cells: cytology (MeSH) ; Neural Stem Cells: metabolism (MeSH) ; Neurogenesis (MeSH) ; Neurons: cytology (MeSH) ; Neurons: metabolism (MeSH) ; Platelet Activation (MeSH) ; Proteome (MeSH)