Journal Article

DZNE-2020-00406

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Progressive Supranuclear Palsy Clinical Deficits Scale.

Piot, I. (First author)DZNE* ; Schweyer, K.DZNE* ; Respondek, G.DZNE* ; Stamelou, M. ; group, D. s. (Collaboration Author) ; group, P. s. (Collaboration Author) ; group, M. P. s. (Collaboration Author) ; Sckopke, P. ; Schenk, T. ; Goetz, C. G. ; Stebbins, G. T. ; Höglinger, G. (Last author)DZNE* ; Gasser, T. ; Hermann, A. ; Höglinger, G. ; Höllerhage, M. ; Kimmich, O. ; Klockgether, T. ; Levin, J. ; Machetanz, G. ; Osterrath, A. ; Palleis, C. ; Prudlo, J. ; Spottke, A. ; Berg, D. ; Bürk, K. ; Claßen, J. ; Eggers, C. ; Greuel, A. ; Grimm, M.-J. ; Hermann, L. ; Iankova, V. ; Jahn, K. ; Jost, W. ; Klietz, M. ; Kühn, A. ; Marxreiter, F. ; Paschen, S. ; Poetter-Nerger, M. ; Preisl, M.-T. ; Prilop, L. ; Tönges, L. ; Trenkwalder, C. ; Warnecke, T. ; Wegner, F. ; Winkler, J. ; Antonini, A. ; P, K. P. ; L, A. L. ; Colosimo, C. ; Compta, Y. ; Corvol, J.-C. ; I, L. I. ; Höglinger, G. U. ; E, A. E. ; Litvan, I. ; R, H. R. ; Nilsson, C. ; Pantelyat, A. ; Respondek, G. ; Stamelou, M.

2020
Wiley New York, NY

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/mds.27964

Abstract: There is currently no undisputed, validated, clinically meaningful measure for deficits in the broad spectrum of PSP phenotypes.To develop a scale to monitor clinical deficits in patients with PSP across its broad phenotypes.The Progressive Supranuclear Palsy Clinical Deficits Scale was conceptualized to cover seven clinical domains (Akinesia-rigidity, Bradyphrenia, Communication, Dysphagia, Eye movements, Finger dexterity, and Gait & balance), each scored from 0 to 3 (no, mild, moderate, or severe deficits). User guidelines were developed to standardize its application. Progressive Supranuclear Palsy Clinical Deficits Scale scores were collected in patients fulfilling the MDS-PSP diagnostic criteria in two independent, multicenter, observational studies, both cross-sectionally (exploratory DescribePSP cohort; confirmatory ProPSP cohort) and longitudinally (12-months' follow-up, both cohorts).Cognitive pretesting demonstrated easy scale utility. In total, 164 patients were scored (70.4 ± 7.6 years; 62% males, 35% variant phenotypes). Mean Progressive Supranuclear Palsy Clinical Deficits Scale completion time was 4 minutes. The Progressive Supranuclear Palsy Clinical Deficits Scale total score correlated with existing scales (e.g., Progressive Supranuclear Palsy Rating Scale: R = 0.88; P < 0.001). Individual Progressive Supranuclear Palsy Clinical Deficits Scale items correlated well with similar constructs in existing scales. Internal consistency (Cronbach's alpha: 0.75), inter-rater reliability (0.96), and test-retest stability (0.99) were acceptable. The PSP-CDS showed significant 12-month change (baseline, 8.6 ± 3.6; follow-up: 10.8 ± 3.6; annualized difference: 3.4 ± 3.4; n = 49; P < 0.0001). Sample sizes required per arm for a two-arm, 1-year follow-up therapeutic trial to detect 50% change in Progressive Supranuclear Palsy Clinical Deficits Scale progression was estimated to be 65 (two-sided, two-sample t test).The Progressive Supranuclear Palsy Clinical Deficits Scale is a rapidly completed, clinimetrically sound scale for clinical care and research involving PSP. © 2020 International Parkinson and Movement Disorder Society.

Keyword(s): Disease Progression (MeSH) ; Female (MeSH) ; Fingers (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Motor Skills (MeSH) ; Reproducibility of Results (MeSH) ; Supranuclear Palsy, Progressive: diagnosis (MeSH)

---

Contributing Institute(s):

1. Translational Neurodegeneration (AG Höglinger)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

---

Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

---