Journal Article

DZNE-2021-00666

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Adult-born neurons promote cognitive flexibility by improving memory precision and indexing.

Berdugo-Vega, G. ; Lee, C.-C. ; Garthe, A.DZNE* ; Kempermann, G.DZNE* ; Calegari, F. (Corresponding author)

2021
Wiley New York, NY [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/hipo.23373

Abstract: Adult neurogenesis in the hippocampal dentate gyrus (DG) is an extraordinary form of plasticity fundamental for cognitive flexibility. Recent evidence showed that newborn neurons differentially modulate input to the infra- and supra-pyramidal blades of the DG during the processing of spatial and contextual information, respectively. However, how this differential regulation by neurogenesis is translated into different aspects contributing cognitive flexibility is unclear. Here, we increased adult-born neurons by a genetic expansion of neural stem cells and studied their influence during navigational learning. We found that increased neurogenesis improved both memory precision and flexibility. Interestingly, each of these gains was associated with distinct subregional patterns of activity and better separation of memory representations in the DG-CA3 network. Our results highlight the role of adult-born neurons in promoting memory precision and indexing and suggests their anatomical allocation within specific DG-CA3 compartments, together contributing to cognitive flexibility.

Keyword(s): Cognition: physiology (MeSH) ; Dentate Gyrus: physiology (MeSH) ; Neural Stem Cells (MeSH) ; Neurogenesis: physiology (MeSH) ; Neurons: physiology (MeSH) ; cognitive flexibility ; hippocampal neurogenesis ; indexing ; memory precision

---

Contributing Institute(s):

1. Technology Platform Neurobiology of Behaviour (AG Garthe)
2. Adult Neurogenesis (AG Kempermann)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2021

---

Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---