Journal Article (Review Article)

DZNE-2021-01189

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Glial Purinergic Signaling in Neurodegeneration.

Pietrowski, M. J. (First author)DZNE* ; Gabr, A.DZNE* ; Kozlov, S.DZNE* ; Blum, D. ; Halle, A.DZNE* ; Carvalho, K.

2021
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fneur.2021.654850

Abstract: Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-specific expression patterns of purinergic signaling components change in neurodegeneration and how dysregulated glial purinergic signaling and crosstalk may contribute to disease pathophysiology, thus bearing promising potential for the development of new therapeutical options for neurodegenerative diseases.

Keyword(s): ATP ; Alzheimer ; adenosine ; astrocyte ; microglia ; neurodegeneration ; oligodendrocyte ; purine

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Contributing Institute(s):

1. Microglia and Neuroinflammation (AG Halle)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2021

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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