Journal Article

DZNE-2022-00693

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Basal metabolic rate and risk of multiple sclerosis: a Mendelian randomization study.

Liu, C. ; Lu, Y. ; Chen, J. ; Qiu, W. ; Zhan, Y.DZNE* ; Liu, Z.

2022
Springer Science + Business Media B.V Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s11011-022-00973-y

Abstract: To determine the relationship between basal metabolic rate (BMR) and multiple sclerosis (MS) susceptibility, we analyzed genome-wide association study (GWAS) summary statistics data from the International Multiple Sclerosis Genetics Consortium on a total of 115,803 participants of European descent, including 47,429 patients with MS and 68,374 controls. We selected 378 independent genetic variants strongly associated with BMR in a GWAS involving 454,874 participants as instrumental variables to examine a potential causal relationship between BMR and MS. A genetically predicted higher BMR was associated with a greater risk of MS (odds ratio [OR]: 1.283 per one standard deviation increase in BMR, 95% confidence interval [CI]: 1.108-1.486, P = 0.001). Moreover, we used the lasso method to eliminate heterogeneity (Q statistic = 384.58, P = 0.370). There was no pleiotropy in our study and no bias was found in the sensitivity analysis using the leave-one-out test. We provide novel evidence that a higher BMR is an independent causal risk factor in the development of MS. Further work is warranted to elucidate the potential mechanisms.

Keyword(s): Basal Metabolism: genetics (MeSH) ; Genome-Wide Association Study (MeSH) ; Humans (MeSH) ; Mendelian Randomization Analysis (MeSH) ; Multiple Sclerosis: epidemiology (MeSH) ; Multiple Sclerosis: genetics (MeSH) ; Polymorphism, Single Nucleotide: genetics (MeSH) ; Basal metabolic rate ; Genome-wide association study ; Mendelian randomization ; Multiple sclerosis

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Contributing Institute(s):

1. Neuroepidemiology (AG Zhan)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Appears in the scientific report 2022

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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