Journal Article (Review Article)

DZNE-2023-01095

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cell type specificity for circuit output in the midbrain dopaminergic system

Blaess, S. ; Krabbe, S. (Last author)DZNE*

2023
Current Biology Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1016/j.conb.2023.102811

Abstract: Midbrain dopaminergic neurons are a relatively small group of neurons in the mammalian brain controlling a wide range of behaviors. In recent years, increasingly sophisticated tracing, imaging, transcriptomic, and machine learning approaches have provided substantial insights into the anatomical, molecular, and functional heterogeneity of dopaminergic neurons. Despite this wealth of new knowledge, it remains unclear whether and how the diverse features defining dopaminergic subclasses converge to delineate functional ensembles within the dopaminergic system. Here, we review recent studies investigating various aspects of dopaminergic heterogeneity and discuss how development, behavior, and disease influence subtype characteristics. We then outline what further approaches could be pursued to gain a more inclusive picture of dopaminergic diversity, which could be crucial to understanding the functional architecture of this system.

Keyword(s): Animals (MeSH) ; Mesencephalon: metabolism (MeSH) ; Brain (MeSH) ; Dopaminergic Neurons: physiology (MeSH) ; Mammals (MeSH)

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Contributing Institute(s):

1. Functional Diversity of Neural Circuits (AG Krabbe)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2023

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