Journal Article (Review Article)

DZNE-2023-01188

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Artificial sharp-wave-ripples to support memory and counter neurodegeneration.

Keil, J. ; Kiiski, H. ; Doherty, L. ; Hernandez-Urbina, V. ; Vassiliou, C.DZNE* ; Dean, C.DZNE* ; Müschenich, M. ; Bahmani, H.

2024
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.brainres.2023.148646

Abstract: Information processed in our sensory neocortical areas is transported to the hippocampus during memory encoding, and between hippocampus and neocortex during memory consolidation, and retrieval. Short bursts of high-frequency oscillations, so called sharp-wave-ripples, have been proposed as a potential mechanism for this information transfer: They can synchronize neural activity to support the formation of local neural networks to store information, and between distant cortical sites to act as a bridge to transfer information between sensory cortical areas and hippocampus. In neurodegenerative diseases like Alzheimer's Disease, different neuropathological processes impair normal neural functioning and neural synchronization as well as sharp-wave-ripples, which impairs consolidation and retrieval of information, and compromises memory. Here, we formulate a new hypothesis, that artificially inducing sharp-wave-ripples with noninvasive high-frequency visual stimulation could potentially support memory functioning, as well as target the neuropathological processes underlying neurodegenerative diseases. We also outline key challenges for empirical tests of the hypothesis.

Keyword(s): Humans (MeSH) ; Hippocampus: physiology (MeSH) ; Neocortex: physiology (MeSH) ; Parietal Lobe (MeSH) ; Memory Consolidation: physiology (MeSH) ; Alzheimer Disease (MeSH) ; Alzheimer ; Gamma ; High-Frequency ; Hippocampus ; Neocortex ; Oscillation ; Ripple ; Theta

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Contributing Institute(s):

1. Synaptic Dysfunction (AG Dean)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2024

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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