Journal Article

DZNE-2024-00056

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.

Erhart, D. K. ; Klose, V.DZNE* ; Schäper, T. ; Tumani, H.Extern* ; Senel, M.

2023
Molecular Diversity Preservation International Basel

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Please use a persistent id in citations: doi:10.3390/ijms25010425

Abstract: C-X-C-motif chemokine ligand 13 (CXCL13) in cerebrospinal fluid (CSF) is increasingly used in clinical routines, although its diagnostic specificity and divergent cut-off values have been defined so far mainly for neuroborreliosis. Our aim was to evaluate the value of CSF-CXCL13 as a diagnostic and treatment response marker and its role as an activity marker in a larger disease spectrum, including neuroborreliosis and other neuroinflammatory and malignant CNS-disorders. Patients who received a diagnostic lumbar puncture (LP) (n = 1234) between July 2009 and January 2023 were included in our retrospective cross-sectional study. The diagnostic performance of CSF-CXCL13 for acute neuroborreliosis was highest at a cut-off of 428.92 pg/mL (sensitivity: 92.1%; specificity: 96.5%). In addition, CXCL13 levels in CSF were significantly elevated in multiple sclerosis with clinical (p = 0.001) and radiographic disease activity (p < 0.001). The clinical utility of CSF-CXCL13 appears to be multifaceted. CSF-CXCL13 is significantly elevated in patients with neuroborreliosis and shows a rapid and sharp decline with antibiotic therapy, but it is not specific for this disease and is also highly elevated in less common subacute neuroinfectious diseases, such as neurosyphilis and cryptococcal meningitis or in primary/secondary B-cell lymphoma.

Keyword(s): Humans (MeSH) ; Cross-Sectional Studies (MeSH) ; Retrospective Studies (MeSH) ; Spinal Puncture (MeSH) ; Multiple Sclerosis (MeSH) ; Neurosyphilis (MeSH) ; Syndrome (MeSH) ; Chemokine CXCL13 (MeSH) ; CXCL13 protein, human ; CNS-inflammatory diseases ; CXCL13 ; cerebrospinal fluid ; neuroborreliosis ; Chemokine CXCL13

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Contributing Institute(s):

1. Neuroepidemiology (AG Zhan)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Appears in the scientific report 2023

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